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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899304 | PMC |
| http://dx.doi.org/10.1016/j.echo.2022.10.006 | DOI Listing |
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Boldine reduces left ventricle oxidative stress in isoproterenol-induced adrenergic overload experimental model.
Arch Physiol Biochem
December 2024
Laboratory of Cardiovascular Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
Sustained adrenergic overload in the heart causes maladaptive cardiac remodelling, which involves oxidative stress. Boldine (BOL) has antioxidant activity and represents a novel therapeutic approach. This study explored the cardioprotective role of BOL in adverse left ventricular remodelling induced by isoproterenol.
View Article and Find Full Text PDFAssociation between allostatic load and cardiac structural and functional abnormalities in young adults with serious mental disorders.
Gen Hosp Psychiatry
December 2024
Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan; Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Objective: Allostatic load refers to the pathophysiological consequences of uncompensated adaptation to chronic stress. Few studies have investigated the effect of allostatic load on cardiac health in patients with serious mental disorders (SMDs), a population at high risk of cardiac mortality. Herein we evaluated associations between allostatic load and cardiac structure and function in young adults with SMDs.
View Article and Find Full Text PDFAssessment of left ventricular systolic function using a non-invasive index of myocardial work in amateur marathon runners.
Quant Imaging Med Surg
December 2024
Department of Ultrasonography, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Article Synopsis
- The study focused on the impact of marathon running on cardiac function in amateur athletes, highlighting the risk of heart fatigue and structural changes like thickening of the ventricular septum.
- It involved 35 amateur runners and 33 healthy controls, using a novel method called the left ventricular pressure-strain loop to analyze heart performance.
- Results indicated that amateur runners had higher global wasted work (GWW) and lower global work efficiency (GWE), with specific parameters showing potential for early detection of cardiac issues.
Zhishi Xiebai Guizhi Decoction modulates hypoxia and lipid toxicity to alleviate pulmonary vascular remodeling of pulmonary hypertension in rats.
Chin Med
December 2024
Department of Medicinal Chemistry and Natural Medicine Chemistry, Department of Pharmacognosy, College of Pharmacy, Harbin Medical University, Harbin, 150081, China.
Background: Pulmonary hypertension (PH) is a severe cardio-pulmonary vascular disease, involves complex molecular mechanism especially during the pathological process of pulmonary vascular remodeling, brings a significant challenge to clinical treatment and thus resulting in high mortality rates. Classic Traditional Chinese medicine formula, Zhishi Xiebai Guizhi Decoction (ZXGD), holds therapeutic potential for PH. In present study, we sought to explore therapeutic potential of ZXGD against PH in rats.
View Article and Find Full Text PDFSpeckle Tracking Echocardiography-Based Correlation Between Left Atrial Strain and Functional Capacity in Patients With Hypertrophic Cardiomyopathy.
Echocardiography
January 2025
Department of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, India.
Introduction: The left atrium (LA) dilates and its function decreases as a chronic secondary change in hypertrophic cardiomyopathy (HCM). LA strain is a more sensitive measure of LV filling pressure than LA volume and can be used to predict the functional capacity in HCM.
Objective: To analyze LA strain in patients with HCM and its correlation with exercise tolerance.
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