AI Article Synopsis
- Herpesviruses like Epstein-Barr virus (EBV) produce various viral microRNAs during different infection stages, which play crucial roles in how the virus interacts with the host.
- Despite progress in laboratory studies of these miRNAs, there's still limited understanding of how they contribute to diseases caused by EBV in real-life situations.
- The review highlights the importance of miRNAs in regulating key cellular processes and discusses recent advancements in using miRNAs for diagnosing and developing treatments for diseases linked to EBV.
Article Abstract
Herpesviruses, such as Epstein-Barr virus (EBV), encode multiple viral microRNAs that are expressed throughout various infection stages. While much progress has been made in evaluating both the viral and host microRNAs (miRNAs) that are detected during infection as well as elucidating their molecular targets in vitro, our understanding of their contributions to pathogenesis in vivo, viral oncogenesis, and clinical implications for these small molecules remains limited. miRNAs are widely recognized as key regulators of global cellular processes, including apoptosis, cell differentiation, and development of immune responses. This review discusses the roles of miRNAs in EBV infection and current advances in miRNA-based diagnostic and therapeutic strategies potentially applicable toward EBV-associated diseases.
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| http://dx.doi.org/10.1016/j.coviro.2022.101272 | DOI Listing |
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