AI Article Synopsis
- * This pathway drives quick gene expression triggered by various extracellular signals like cytokines and interleukins.
- * Research on the JAK-STAT pathway has led to treatments for several conditions, including autoimmune diseases and COVID-19, but there are still significant challenges in understanding and leveraging this pathway.
Article Abstract
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in cell signaling conserved from slime molds to mammals. These discoveries revealed mechanisms underlying rapid gene expression mediated by a wide variety of extracellular polypeptides including cytokines, interleukins, and related factors. This knowledge has provided numerous insights into human disease, from immune deficiencies to cancer, and was rapidly translated to new drugs for autoimmune, allergic, and infectious diseases, including COVID-19. Despite these advances, major challenges and opportunities remain.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815833 | PMC |
| http://dx.doi.org/10.1016/j.cell.2022.09.023 | DOI Listing |
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