AI Article Synopsis
- Acute diarrhea is common among travelers, and the study investigates how sleep affects susceptibility to infection, specifically looking at enterotoxigenic E. coli (ETEC).
- Conducted during a controlled human infection model, researchers monitored sleep over eight days, hypothesizing that better sleep before exposure would result in milder symptoms.
- Findings revealed that while overall sleep did not directly influence diarrhea incidence, less sleep the night before exposure led to increased severity of diarrhea, indicating a potential link between sleep quality and infection outcomes.
Article Abstract
Background: Acute diarrhea is the most frequent diagnosis among ill travelers. Sleep loss may weaken the body's defense against pathogens and increase susceptibility to infection. The relationship between sleep and infectious diarrhea has not been studied and was assessed utilizing data from a controlled human infection model (CHIM) for enterotoxigenic Escherichia coli (ETEC).
Methods: During a CHIM assessing the efficacy of an immunoprophylactic targeting ETEC against moderate-to-severe diarrhea (MSD) following challenge, we measured sleep via actigraphy over an 8-day inpatient period. We hypothesized better sleep pre-challenge would predict illness symptomatology following challenge.
Results: Among 57 participants (aged 34.4 ± 8.1 years, 64% male), there was no relationship between sleep metrics and incidence of MSD. However, longer total sleep time the night preceding ETEC challenge was associated with lower maximum 24 h diarrhea volume (B = -1.80, p = 0.01) and total diarrhea volume (B = -2.45, p = 0.01).
Conclusions: This novel study showed that shorter sleep duration predicted diarrhea severity over the course of an ETEC infection. Future work should experimentally manipulate sleep to further clarify its impact on diarrhea-related outcomes for ETEC and other important enteric pathogens.
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| http://dx.doi.org/10.1016/j.sleep.2022.09.008 | DOI Listing |
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