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Neuromuscular Blockade in Adult Respiratory Distress Syndrome.
Clin Chest Med
December 2024
Department of Anesthesiology, Critical Care and Pain, Tata Memorial Hospital, Dr. E Borges Road, Mumbai, Maharashtra 400012, India.
Although current clinical practice guidelines have discordant conclusions, a judicious approach to using NMBA infusions may include reserving their use for patients with early severe ARDS who are already deeply sedated and for patients under light sedation who have significant ventilator dyssynchrony, despite attempts to adjust both ventilator settings and sedation requirements. Based on current evidence, the duration of NMBA use should be limited to 48 hours, whenever possible.
View Article and Find Full Text PDF[Analysis of clinical treatment of acute respiratory distress syndrome assisted by artificial intelligence].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
April 2024
Department of Critical Care Medicine, Hebei General Hospital, Shijiazhuang 050051, Hebei, China. Yang Zhiwei is working on the Department of Critical Care Medicine, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China. Corresponding author: Du Quansheng, Email:
Objective: To evaluate the clinical practice of intensive care unit (ICU) physicians at Hebei General Hospital in identifying patients meeting the diagnostic criteria for acute respiratory distress syndrome (ARDS) and the current status of invasive mechanical ventilation management and adjunctive therapy in these patients, and to analyze the incidence and clinical outcomes of ARDS.
Methods: A retrospective cohort study was conducted. The patients who were hospitalized in the ICU of Hebei General Hospital from April 10, 2017 to June 30, 2022 and met the Berlin definition diagnostic criteria for ARDS were enrolled as study subjects.
Effects of sevoflurane on lung alveolar epithelial wound healing and survival in a sterile in vitro model of acute respiratory distress syndrome.
Exp Cell Res
May 2024
iGReD, Université Clermont Auvergne, CNRS, INSERM, Clermont-Ferrand, France; Department of Perioperative Medicine, CHU Clermont-Ferrand, Clermont-Ferrand, France. Electronic address:
Acute respiratory distress syndrome (ARDS) is a serious lung condition that often leads to hospitalization in intensive care units and a high mortality rate. Sevoflurane is a volatile anesthetic with growing interest for sedation in ventilated patients with ARDS. It has been shown to have potential lung-protective effects, such as reduced inflammation and lung edema, or improved arterial oxygenation.
View Article and Find Full Text PDFPhysical rehabilitation while awake, intubated and proned for COVID-19-associated severe acute respiratory distress syndrome.
BMJ Case Rep
February 2024
Pulmonary and Critical Care Medicine/Physical Medicine & Rehabilitation, Johns Hopkins University, Baltimore, Maryland, USA.
This case study demonstrates the implementation of evidence-based guidelines in the intensive care unit setting, including light sedation and early physical rehabilitation while receiving prone positioning and lung protective mechanical ventilation for severe acute respiratory distress syndrome from SARS-CoV-2 infection.
View Article and Find Full Text PDFEffects on mechanical power of different devices used for inhaled sedation in a bench model of protective ventilation in ICU.
Ann Intensive Care
January 2024
Hospices Civils de Lyon, Service de Médecine Intensive -Réanimation, Hôpital Edouard Herriot, 5 Place d'Arsonval, 69437, Lyon Cedex 03, France.
Background: Inhaled sedation during invasive mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) has received increasing attention. However, inhaled sedation devices increase dead-space ventilation and an undesirable effect is the increase in minute ventilation needed to maintain CO removal. A consequence of raising minute ventilation is an increase in mechanical power (MP) that can promote lung injury.
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