AI Article Synopsis
- The research focuses on creating new types of metallosupramolecular structures called metallacages, which could be used for therapy and diagnosis (theranostics), featuring F-labelled [Pd L].
- Various spectroscopic and bio-analytical techniques demonstrate the successful formation of a complex between the metallacage and the chemotherapy drug cisplatin.
- The study examines how the metallacage, with or without cisplatin, distributes throughout the bodies of healthy mice using PET/CT imaging and ICP-MS analysis.
Article Abstract
To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of F-labelled [Pd L ] metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168593 | PMC |
| http://dx.doi.org/10.1002/chem.202202604 | DOI Listing |
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