The ability to transition between different behavioural stages is a widespread phenomenon across the animal kingdom. Such behavioural adaptations are often linked to changes in the sensitivity of those neurons that sense chemical cues associated with the respective behaviours. To identify the genetic mechanisms that regulate neuronal sensitivity, and by that behaviour, typically *omics approaches, such as RNA- and protein-sequencing, are applied to sensory organs of individuals displaying differences in behaviour. In this review, we discuss these genetic mechanisms and how they impact neuronal sensitivity, summarize the correlative and functional evidence for their role in regulating behaviour and discuss future directions. As such, this review can help interpret *omics data by providing a comprehensive list of already identified genes and mechanisms that impact behaviour through changes in neuronal sensitivity.
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http://dx.doi.org/10.1111/mec.16739 | DOI Listing |
Elife
January 2025
Cell Biology, Hospital for Sick Children, Toronto, Canada.
Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that cell size control involves both cell size checkpoints, which delay cell cycle progression in small cells, and size-dependent regulation of mass accumulation rates (Ginzberg et al., 2018).
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January 2025
Department of Biology, Technion - Israel Institute of Technology, Haifa, Israel.
Dendrites are crucial for receiving information into neurons. Sensory experience affects the structure of these tree-like neurites, which, it is assumed, modifies neuronal function, yet the evidence is scarce, and the mechanisms are unknown. To study whether sensory experience affects dendritic morphology, we use the arborized nociceptor PVD neurons, under natural mechanical stimulation induced by physical contacts between individuals.
View Article and Find Full Text PDFEur J Ophthalmol
January 2025
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Background: To describe a case of guttae recurrence in bilateral corneal grafts in a patient with a known diagnosis of Fuchs endothelial dystrophy, more than three decades following penetrating keratoplasty.
Methods: Case Report.
Results: A 79-year-old White woman presented with declining vision, right eye worse than the left.
Ann Neurol
January 2025
Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.
Objective: Approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Epidemiological data have identified traumatic brain injury (TBI) as an exogenous risk factor for ALS; however, the mechanisms by which TBI may worsen SOD1 ALS remain largely undefined.
Methods: We sought to determine whether repetitive TBI (rTBI) accelerates disease onset and progression in the transgenic SOD1 mouse ALS model, and whether loss of the primary regulator of axonal degeneration sterile alpha and TIR motif containing 1 (Sarm1) mitigates the histological and behavioral pathophysiology.
Yi Chuan
January 2025
Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Being the most magnificent plateau in elevation and size on Earth, the Qinghai-Tibet Plateau has a profound impact on biodiversity due to the unique geographic and climatic conditions. Here we review the speciation patterns and genetic diversity of the birds from the Qinghai-Tibet Plateau in relation to the geological history and climatic changes. First, the uplift of the Qinghai-Tibet Plateau forms a geographic barrier and promotes interspecific and intraspecific genetic differentiation.
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