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Screening of medicinal plants from El Salvador for anti-viral activity against Herpes simplex 1. | LitMetric
Herpes simplex virus 1 is one of the most prevalent pathogens worldwide. Resistant strains to current anti-viral treatment have been reported, requiring the search for novel anti-virals. Using a qPCR method to assess anti-herpetic activity from natural products, we analyzed 72 plant extracts from El Salvador and identified eighteen methanolic extracts with anti-viral activity of ≥ 75%. Anti-herpetic activity has not been previously reported in fourteen of the plants (, , , , , , , , , , , , ). Four extracts were from species with previously reported anti-herpetic activity (, , ). These extracts effective anti-viral concentrations (EC) were between 203 and 6.31 µg/mL, while the selectivity indexes (SI) were between 55.91 and 2.57. showed the most effective anti-viral activity (EC = 6.31 µg/mL, SI = 51.82).
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