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| http://dx.doi.org/10.1002/joa3.12775 | DOI Listing |
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Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices.
J Cardiovasc Dev Dis
August 2023
Medical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, Greece.
Cardiac amyloidosis (CA) is a rare but potentially life-threatening disease in which misfolded proteins accumulate in the cardiac wall tissue. Heart rhythm disorders in CA, including supraventricular arrhythmias, conduction system disturbances, or ventricular arrhythmias, play a major role in CA morbidity and mortality, and thus require supplementary management. Among them, AF is the most frequent arrhythmia during CA hospitalizations and is associated with significantly higher mortality, while ventricular arrhythmias are also common and are usually associated with poor prognosis.
View Article and Find Full Text PDFDigoxin Use in Cardiac Amyloidosis.
Am J Cardiol
October 2020
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:
Despite limited options for rate control of atrial fibrillation and for low-output heart failure seen in cardiac amyloidosis (CA), digoxin use is discouraged due to a reported increased risk of sensitivity and toxicity. We present our experience with digoxin use in patients with CA and report the event rate of suspected digoxin-related arrhythmias and toxicity. This is a retrospective study of patients with CA seen at our institution between November 1995 and October 2018.
View Article and Find Full Text PDFManagement of Arrhythmias in Cardiac Amyloidosis.
JACC Clin Electrophysiol
April 2020
Cardiac Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, California, USA. Electronic address:
Cardiac amyloidosis is characterized by extracellular protein fibril deposition in the myocardium leading to restrictive heart failure. Both atrial and ventricular arrhythmias, along with conduction disease, are common in cardiac amyloidosis, and are often highly symptomatic and poorly tolerated. Many commonly used therapeutics such as beta-blockers, calcium-channel blockers, and digoxin may be poorly tolerated and lead to clinical decompensation in this population, adding complexity to the co-management of these conditions.
View Article and Find Full Text PDFAmyloid Cardiomyopathy in the Emergency Department.
J Emerg Med
February 2019
Department of Emergency Medicine, Mount Sinai Medical Center, Miami Beach, Florida; Emergency Department Ultrasonography, Mount Sinai Medical Center, Miami Beach, Florida.
Background: Cardiac amyloidosis is an underdiagnosed cause of restrictive cardiomyopathy resulting from the infiltration of the myocardium by amyloid proteins.
Case Report: We report the case of an 83-year-old woman who presented with increasing dyspnea and lower-extremity swelling. She reported a medical history of unspecified heart failure.
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