The history of Compton cameras began with the detection of radiation sources originally for applications in astronomy. A Compton camera is a promising γ-ray detector that operates in the wide energy range of a few tens of keV to MeV. The γ-ray detection method of a Compton camera is based on Compton scattering kinematics, which is used to determine the direction and energy of the γ-rays without using a mechanical collimator. Although the Compton camera was originally designed for astrophysical applications, it was later applied in medical imaging as well. Moreover, its application in environmental radiation measurements is also under study. Although a few review papers regarding Compton cameras have been published, they either focus very specifically on the detectors used in such cameras or the particular applications of Compton cameras. Thus, the aim of this paper is to review the features and types of Compton cameras and introduce their applications, associated imaging algorithms, improvement scopes, and their future aspects.
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http://dx.doi.org/10.3390/s22197374 | DOI Listing |
Phys Med Biol
January 2025
CREATIS, INSA de Lyon, Bâtiment Blaise Pascal, 7 Avenue Jean Capelle, Villeurbanne, 69621 Cedex , FRANCE.
Compton cameras are imaging devices that may improve observation of sources of γ photons. We present CoReSi, a Compton Reconstruction and Simulation software implemented in Python and powered by PyTorch to leverage multi-threading and for easy interfacing with image processing and deep learning algorithms. The code is mainly dedicated to medical imaging and for near-field experiments where the images are reconstructed in 3D.
View Article and Find Full Text PDFAppl Radiat Isot
March 2025
Instituto de Física Corpuscular (CSIC-Universidad de Valencia), Valencia, Spain.
This paper explores the adaptation and application of i-TED Compton imagers for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED array, previously utilized in nuclear astrophysics experiments at CERN, is being optimized for detecting and imaging 478 keV gamma-rays, critical for accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize the i-TED detector configuration and enhance its performance in the challenging radiation environment typical of BNCT.
View Article and Find Full Text PDFCancers (Basel)
January 2025
Istituto Nazionale di Fisica Nucleare, Sezione di Bari, 70125 Bari, Italy.
Background: Boron neutron capture therapy (BNCT) is an innovative binary form of radiation therapy with high selectivity towards cancer tissue based on the neutron capture reaction B(n,α)Li, consisting in the exposition of patients to neutron beams after administration of a boron compound with preferential accumulation in cancer cells. The high linear energy transfer products of the ensuing reaction deposit their energy at the cell level, sparing normal tissue. Although progress in accelerator-based BNCT has led to renewed interest in this cancer treatment modality, in vivo dose monitoring during treatment still remains not feasible and several approaches are under investigation.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Freiburg Materials Research Center, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg im Breisgau, Germany.
Nuclear power plant decommissioning requires the rapid and accurate classification of radioactive waste in narrow spaces and under time constraints. Photon-counting detector technology offers an effective solution for the quick classification and detection of radioactive hotspots in a decommissioning environment. This paper characterizes a 5 mm CdTe Timepix3 detector and evaluates its feasibility as a single-layer Compton camera.
View Article and Find Full Text PDFIEEE Trans Radiat Plasma Med Sci
November 2024
University of California, Santa Cruz, Electrical and Computer Engineering, Santa Cruz, 95064, USA.
In this article, we investigate quantum entanglement (QE) filtering to address the challenges in multi-isotope positron emission tomography (PET) or in PET studies utilizing radiotracers with dual- positron and prompt gamma emissions. Via GATE simulation, we demonstrate the efficacy of QE filtering using a one-of-a-kind cadmium zinc telluride (CZT) PET system - establishing its viability as a multimodal scanner and ability to perform QE filtering. We show the high Compton scattering probability in this CZT-based scanner with 44.
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