The automation of water leakage detection and monitoring systems has recently been made possible by the Internet of Things (IoT). However, the high cost is an obstacle when applying a network over a large area. The Low-Power Wide-Area Network (LPWAN) was created specifically to address long-range IoT applications. The Long-Range Wide-Area Network (LoRaWAN) is one of the most common LPWANs. In this study, a method for monitoring and detecting water leakage in a housing complex was tested using LoRaWAN. Water leakage was detected using a low-pressure system model comprising a water meter, presser sensor, and smart valve within a LoRa node. This study investigates the use of LoRaWAN for water monitoring and leakage detection by implementing a comprehensive case study to identify LoRaWAN's feasibility, reliability, and scalability for water monitoring and leakage detection in simulated scenarios. The housing complex varied in size and number of nodes. The LoRaWAN was evaluated by the FloRa simulator package through the Objective Modular Network Testbed (OMNeT++) platform. The results indicated that it was an efficient means of water monitoring and leakage detection in housing complexes.
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http://dx.doi.org/10.3390/s22197188 | DOI Listing |
J Pharm Biomed Anal
December 2024
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. Electronic address:
Qingwen Zhike prescription (QWZK), a traditional Chinese medicine (TCM) hospital prescription developed in response to the corona virus disease 2019 (COVID-19) pandemic, has demonstrated efficacy in clinical practice. Nevertheless, its specific antiviral components and mechanisms of action remain unclear. This study screened the antiviral compounds against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from Qingwen Zhike prescription and explored the underlying mechanism through chemical composition analysis, serum and lung exposure profiles analysis, high-throughput screening, and transmission electron microscopy (TEM) observation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Miami, Coral Gables, FL, USA.
Background: Despite being the second most common form of dementia, vascular contributions of Frontotemporal Dementia are understudied. Recent data from patients and preliminary experiments have indicated that in progranulin-deficient mice, an increased number of cortical capillaries are stalled, and cerebral blood flow is reduced. Here, we examined the underlying mechanism contributing to microvascular dysfunction in FTD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Augusta University, Augusta, GA, USA.
Background: Hypertension is a leading risk factor for the development of Alzheimer's disease and Alzheimer's disease-related dementia (AD/ADRD), which is closely linked with cerebral vascular inflammation and dysfunction. We previously found that high-salt-treated Dahl Salt-Sensitive (SS) rats displayed blood-brain barrier (BBB) leakage, astrocyte activation, neurodegeneration, and cognitive impairments. CD14 functions in the Toll-like receptor 4 (TLR4) complex to initiate proinflammatory signaling events in response to LPS.
View Article and Find Full Text PDFJ Pediatr Ophthalmol Strabismus
December 2024
Purpose: To investigate whether wide-angle fluorescein angiography (FA) was useful for detecting familial exudative retinopathy (FEVR) in patients with neurodevelopmental disorder with spastic diplegia and visual defects (NEDSDV).
Methods: This was a retrospective chart review from 2013 to 2023 of all consecutive patients with NEDSDV and pathogenic or likely pathogenic variants.
Results: Seven patients (four females, three males) were seen in the ophthalmology clinic (median age: 14 months).
Dan Med J
November 2024
Department of Gastrointestinal Surgery, Aarhus University Hospital.
Introduction: Refractory malignant ascites (RMA) is a manifestation of end-stage cancer disease with a major impact on quality of life due to the symptom burden and need for repeated hospitalisations. We previously described the implantation of the permanent PleurX catheter as a treatment of RMA. The present study aimed to evaluate and describe our experience with the permanent PleurX catheter system in the largest cohort to date.
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