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Poly(2-oxazoline)s are the synthetic polymers that are the products of the cationic ring-opening polymerization (CROP) of 2-oxazoline monomers. Due to their beneficial properties, from which biocompatibility, stealth behavior, high functionalization possibilities, low dispersity, stability, nonionic character, and solubility in water and organic solvents should be noted, they have found many applications and gained enormous interest from scientists. Additionally, with high versatility attainable through copolymerization or through post-polymerization modifications, this class of polymeric systems has been widely used as a polymeric platform for novel biomedical applications. The chemistry of polymers significant expanded into biomedical applications, in which polymeric networks can be successfully used in pharmaceutical development for tissue engineering, gene therapies, and also drug delivery systems. On the other hand, there is also a need to create 'smart' polymer biomaterials, responsive to the specified factor, that will be sensitive to various environmental stimuli. The commonly used stimuli-responsive biomedical materials are based mostly on temperature-, light-, magnetic-, electric-, and pH-responsive systems. Thus, creating selective and responsive materials that allow personalized treatment is in the interest of the scientific world. This review article focuses on recent discoveries by Polish scientists working in the field of stimuli-responsive poly(2-oxazoline)s, and their work is compared and contrasted with results reported by other world-renowned specialists.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572872 | PMC |
http://dx.doi.org/10.3390/polym14194176 | DOI Listing |
Discov Nano
December 2024
Department of Instrumentation and Control Engineering, Dr B R Ambedkar National Institute of Technology Jalandhar, Punjab, 144008, India.
In vivo, molecular imaging is prevalent for biology research and therapeutic practice. Among advanced imaging technologies, photoacoustic (PA) imaging and sensing is gaining interest around the globe due its exciting features like high resolution and good (~ few cm) penetration depth. PA imaging is a recent development in ultrasonic technology that generates acoustic waves by absorbing optical energy.
View Article and Find Full Text PDFCurr Protoc
December 2024
Department of Biomedical Sciences, University of Padova, Padova, Italy.
Intrinsically disordered proteins (IDPs) make up around 30% of eukaryotic proteomes and play a crucial role in cellular processes and in pathological conditions such as neurodegenerative disorders and cancers. However, IDPs exhibit dynamic conformational ensembles and are often involved in the formation of biomolecular condensates. Understanding the function of IDPs is critical to research in many areas of science.
View Article and Find Full Text PDFJ Biomed Mater Res A
January 2025
BYU Applied Biomedical Engineering Laboratory, Brigham Young University, Provo, Utah, USA.
Wearable nanocomposite stretch sensors are an exciting new development in biomaterials for biomechanical motion-tracking technology, with applications in the treatment of low back pain, knee rehabilitation, fetal movement tracking, and other fields. When strained, the resistance of the low-cost sensors is reduced, enabling human motion to be monitored using a suitable sensor array. However, current sensor technologies have exhibited significant drift, in the form of increased electrical resistance, if left stored in typical room conditions.
View Article and Find Full Text PDFJ Biomed Mater Res A
January 2025
Ovcharenko Institute of Biocolloidal Chemistry of the Ukrainian National Academy of Sciences of Ukraine, Kyiv, Ukraine.
This study presents an innovative approach to improve implant biointegration and reduce implant-associated infections using porous poly(vinyl formal) nanocomposite matrices incorporated with gold nanoparticles and antimicrobial/anticancer drugs for plastic surgery applications. The porous matrices were characterized using physicochemical techniques and in vitro biochemical assays. The results demonstrated the biocompatibility of PVF nanocomposites and their potential for functionalization with various bioactive molecules and drugs, thereby enhancing their therapeutic efficacy.
View Article and Find Full Text PDFJ Med Chem
December 2024
Biochemistry and Structural Biology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
The quest for new approaches for generating novel bioactive designer proteins/peptides has continued with their success in various biomedical applications. Previously, we designed a 14-mer α-helical peptide with antimicrobial and antimycobacterial activities by employing a tandem repeat of the 7-mer, "KVLGRLV" human chemerin segment. Herein, we devised a new method of "sliding framework" with this segment to create amino acid scaffolds of varying sizes and sequences and explored the design of a peptide library with antibacterial and antimycobacterial activities.
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