AI Article Synopsis
- TMAO and indoxyl sulfate (IS) are linked to brain aging and cognitive issues, and this study investigates their levels in patients with alcohol-use disorder (AUD) versus healthy controls.
- In a comparison of 30 AUD patients to 15 healthy individuals, TMAO levels were similar, but significant differences in nutritional and liver function biomarkers were found among AUD patients with lower TMAO.
- IS levels were notably lower in AUD patients and positively correlated with serum prealbumin changes, indicating potential benefits from personalized nutrition during alcohol withdrawal, despite no links to AUD severity or cognitive impairments.
Article Abstract
Background: Trimethylamine -oxide (TMAO) and indoxyl sulfate (IS) are produced by the microbiota and the liver, and can contribute to brain aging and impaired cognitive function. This study aims to examine serum TMAO and IS concentrations in patients with alcohol-use disorder (AUD) at the entry for alcohol withdrawal, and the relationships with several biological, neuropsychological, and clinical parameters.
Methods: TMAO and IS were quantified in thirty AUD inpatients and fifteen healthy controls (HC). The severities of AUD and alcohol withdrawal syndrome (AWS), and general cognitive abilities were assessed in AUD patients.
Results: TMAO concentrations did not differ between HC and AUD patients. Several biomarkers assessing nutritional status and liver function were significantly different in AUD patients with the lowest TMAO concentrations compared to other AUD patients. IS concentration was significantly lower in AUD patients and a significant positive predictor of serum prealbumin variation during the acute phase of alcohol withdrawal. No relationship was observed between the concentrations of these metabolites and the severities of alcohol dependence, AWS, or cognitive deficits.
Conclusions: Our data suggest that AUD patients with low concentrations of TMAO or IS should probably benefit from a personalized refeeding program during the acute phase of alcohol withdrawal.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572718 | PMC |
| http://dx.doi.org/10.3390/nu14193964 | DOI Listing |
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