AI Article Synopsis
- Fibroblast growth factor 21 (FGF21) is important for regulating glucose and lipid metabolism, which can help treat metabolic diseases.
- Researchers tested a library of compounds from medicinal herbs and found that a root extract and its component, wogonin, can activate FGF21 expression in liver cells.
- Wogonin also boosts the expression of activating transcription factor 4 (ATF4) through a different mechanism and is essential for wogonin's activation of FGF21, suggesting it's a potential treatment for metabolic disorders.
Article Abstract
Fibroblast growth factor 21 (FGF21), which is mainly synthesized and secreted by the liver, plays a crucial role in systemic glucose and lipid metabolism, ameliorating metabolic diseases. In this study, we screened the WAKANYAKU library derived from medicinal herbs to identify compounds that can activate expression in mouse hepatocyte AML12 cells. We identified root extract and one of its components, wogonin, as an activator of expression. Wogonin also enhanced the expression of activating transcription factor 4 (ATF4) by a mechanism other than ER stress. Knockdown of ATF4 by siRNA suppressed wogonin-induced expression, highlighting its essential role in wogonin's mode of action. Thus, our results indicate that wogonin would be a strong candidate for a therapeutic to improve metabolic diseases by enhancing hepatic FGF21 production.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572861 | PMC |
| http://dx.doi.org/10.3390/nu14193920 | DOI Listing |
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