AI Article Synopsis
- A new portable laser system was tested for analyzing essential electrolytes (K, Na, Ca) in human blood serum using laser-induced breakdown spectroscopy (LIBS).
- The study employed partial least squares regression (PLSR) to predict the concentrations of these electrolytes from the LIBS data, achieving high prediction accuracy.
- Results showed that the portable LIBS system, capable of real-time analysis, could significantly benefit clinical practices for detecting and diagnosing diseases.
Article Abstract
The fast and reliable analysis of electrolytes such as K, Na, Ca in human blood serum has become an indispensable tool for diagnosing and preventing diseases. Laser-induced breakdown spectroscopy (LIBS) has been demonstrated as a powerful analytical technique on elements. To apply LIBS to the quantitative analysis of electrolyte elements in real time, a self-developed portable laser was used to measure blood serum samples supported by glass slides and filter paper in this work. The partial least squares regression (PLSR) method was employed for predicting the concentrations of K, Na, Ca from serum LIBS spectra. Great prediction accuracies with excellent linearity were obtained for the serum samples, both on glass slides and filter paper. For blood serum on glass slides, the prediction accuracies for K, Na, Ca were 1.45%, 0.61% and 3.80%. Moreover, for blood serum on filter paper, the corresponding prediction accuracies were 7.47%, 1.56% and 0.52%. The results show that LIBS using a portable laser with the assistance of PLSR can be used for accurate quantitative analysis of elements in blood serum in real time. This work reveals that the handheld LIBS instruments will be an excellent tool for real-time clinical practice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573104 | PMC |
| http://dx.doi.org/10.3390/molecules27196438 | DOI Listing |
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