Current Progress in the Chemoenzymatic Synthesis of Natural Products.

Molecules

Department of Chemistry, Rollins College, Winter Park, FL 32789, USA.

Published: September 2022

AI Article Synopsis

  • * The synthesis field focuses on improving methods for better stereoselectivity, higher yields, and more versatile reactions.
  • * Recent advancements from 2019-2022 in chemoenzymatic reactions showcase unique ways to synthesize natural products.

Article Abstract

Natural products, with their array of structural complexity, diversity, and biological activity, have inspired generations of chemists and driven the advancement of techniques in their total syntheses. The field of natural product synthesis continuously evolves through the development of methodologies to improve stereoselectivity, yield, scalability, substrate scope, late-stage functionalization, and/or enable novel reactions. One of the more interesting and unique techniques to emerge in the last thirty years is the use of chemoenzymatic reactions in the synthesis of natural products. This review highlights some of the recent examples and progress in the chemoenzymatic synthesis of natural products from 2019-2022.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571504PMC
http://dx.doi.org/10.3390/molecules27196373DOI Listing

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