Five new furofurans lignans, Brasesquilignan A-E (), were isolated from the aqueous ethanol extract of Baker. Their structures were elucidated by extensive analysis of NMR and HRESIMS data. Their absolute configurations were determined by CD spectra, enzymatic hydrolysis, and GCMS analysis. Furthermore, all compounds were evaluated for anti-proliferative activities against various human cancer cellsin vitro. Compounds and exhibited weak inhibitorypotency against five human cancer cells.
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http://dx.doi.org/10.3390/molecules27196349 | DOI Listing |
Molecules
September 2022
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Five new furofurans lignans, Brasesquilignan A-E (), were isolated from the aqueous ethanol extract of Baker. Their structures were elucidated by extensive analysis of NMR and HRESIMS data. Their absolute configurations were determined by CD spectra, enzymatic hydrolysis, and GCMS analysis.
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