Cement-improved loess (CIL) is used as a common filler for subgrade construction projects in loess areas. The freeze-thaw (F-T) conditions have a significant effect on the stability of cement-improved loess subgrades in seasonally frozen regions. In this paper, the CIL samples, experiencing different numbers of F-T cycles at varying freezing temperatures, were used in consolidated undrained triaxial compression tests to investigate the effect of F-T conditions on the mechanical properties of CIL. The results show the stress-strain curves of CIL are of a strain-softening type with strong elastic brittleness. The initial tangent modulus of CIL increases with the growing confining pressure and gradually decreases with the increase in the F-T cycle number and the decreasing freezing temperature. It loses 46.4% of its original value after the twelfth F-T cycle with the confining pressure of 150 kPa and at the freezing temperature of -15 °C. The strength of CIL decreases with the increasing F-T cycle number, but it gradually tends to keep stable after the sixth F-T cycle. The strength also decreases with the reduction in the freezing temperature. It loses 37.7% of its original value after the twelfth F-T cycle with the confining pressure of 150 kPa and the freezing temperature of -15 °C. To express the nonlinearity correlation between the strength and confining pressure under F-T conditions, the Weibull function was applied and a nonlinear Mohr-Coulomb strength criterion was proposed. Through introducing a breakage rate function and a local strain coefficient, a binary-medium constitutive model consisting of bonded elements (soil-particle cohesion) and frictional elements (soil particles or soil aggregations) was established to describe the stress-strain relationships of CIL under F-T conditions. The test results indicated that the model can well describe the strain-softening phenomenon of the stress-strain curve of CIL and reflect the breakage mechanism of CIL.
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http://dx.doi.org/10.3390/ma15197042 | DOI Listing |
Food Chem
January 2025
College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. Electronic address:
In this study, the effect of freeze-thaw (F-T) processes on the mechanical and water absorption performance of citrate cross-linked chitosan/poly(vinyl alcohol) hydrogel pads was evaluated. An excellent cross-linking of 4 % (w/w) citrate was indicated by enhanced peak strength in Fourier-transform infrared spectroscopy and X-ray diffraction patterns, which was applied to the subsequent F-T process. The results in the deswelling rate, water contact angle, and relaxation time of samples exhibited a tendency to decrease and then increase with increasing F-T cycles, reaching a minimum of 0.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Ruicheng Construction Engineering Co., Ltd., Lianyungang 222042, China.
The deterioration of concrete structures is mainly due to the combined action of the environment and external load. In this study, 32 reinforced concrete columns were prepared to evaluate the coupling actions on the properties of reinforced concrete structures. The durability, bearing capacity, and failure mode of reinforced concrete columns were investigated under the combined action of freeze-thaw (F-T) cycles, sustained load, and salt corrosion (water or composite salt solution).
View Article and Find Full Text PDFPLoS One
December 2024
Civil Engineering Department, Lanzhou Jiaotong University, Lanzhou, China.
The Belt and Road strategy has significantly advanced the scale of infrastructure construction in the Qinghai-Tibet Plateau permafrost area. Consequently, this demands higher requirements on the strength and frost resistance of concrete (FRC) cured under low-temperature and negative-temperature conditions. Accordingly, in this study, tests on the mechanical properties and FRC were conducted under standard curing, 5 °C curing, and -3 °C curing conditions.
View Article and Find Full Text PDFClin Pharmacokinet
December 2024
Clinical Pharmacology and Quantitative Science, Genmab, Plainsboro, NJ, USA.
Background And Objectives: Epcoritamab is a CD3xCD20 bispecific antibody approved for the treatment of adults with different types of relapsed or refractory (R/R) B cell non-Hodgkin lymphoma (B-NHL) after ≥ 2 lines of systemic therapy. Here we report the first results from a population pharmacokinetic model-based analysis using data from 2 phase 1/2 clinical trials (EPCORE NHL-1, NCT03625037 and EPCORE NHL-3, NCT04542824) evaluating epcoritamab in patients with R/R B-NHL.
Methods: Plasma concentration-time data included 6819 quantifiable pharmacokinetic samples from 327 patients with R/R B-NHL.
Nat Rev Drug Discov
January 2025
Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
The DNA damage response (DDR) is a network of proteins that coordinate DNA repair and cell-cycle checkpoints to prevent damage being transmitted to daughter cells. DDR defects lead to genomic instability, which enables tumour development, but they also create vulnerabilities that can be used for cancer therapy. Historically, this vulnerability has been taken advantage of using DNA-damaging cytotoxic drugs and radiotherapy, which are more toxic to tumour cells than to normal tissues.
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