The deep drawing behavior of metal-composite sandwich plates, or fiber-metal laminates, in which aluminum or steel sheets are used as the face layer and composite materials are used as the core layer, is discussed in this work to find the workpieces without fractures and wrinkles. Two types of aluminum, 1050 and 6061, are considered their suitability as face sheets. The preheat effect of aluminum 6061 on formability is also investigated. When steel sheets are used, the effect of blank-holder pressure is included. In addition, to understand the deformation of fabric composite, pure composite laminates are deep drawn. The results of composite laminates show that after drawing, the weft and warp lines are shorter than the other radial lines, causing the specific deformed shape and the variation of the fiber intersection angle. For Al-composite sandwich plates, fractures and wrinkles are easy to occur. Even though the fracture and wrinkle conditions are released with the increase in preheating temperature of aluminum 6061, it may be not enough. For the deep drawing of the steel-composite sandwich plates, in which fractures are avoided, the increase of blank-holder pressure could reduce the wrinkle number. Hence, good quality workpieces without fracture and wrinkle could be obtained when the blank-holder pressure is high enough.
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http://dx.doi.org/10.3390/ma15196612 | DOI Listing |
J Pharm Sci
December 2024
Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark. Electronic address:
Physiological and artificial solubilizing agents usually enhance apparent solubility of poorly soluble drugs, and in many cases also oral drug exposure. However, exposure may decrease in cases where micellization reduces the molecularly dissolved drug fraction, overriding the solubility advantage. While this information is critical to accurately anticipate the effect of drug micellization on oral absorption, the experimental determination of molecularly dissolved drug concentrations is complex and time consuming.
View Article and Find Full Text PDFTalanta
December 2024
Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Chongqing University, Shapingba, Chongqing, 400044, China; School of Optoelectronics Engineering, Chongqing University, Shapingba, Chongqing, 400044, China. Electronic address:
A multifunctional microfluidic chip integrated with perfusion cell culture and in situ SERS detection of cell secretion was designed and developed for the detection of IL-6 secretion from LPS-stimulation of A549 cells in this paper. Researching works were focused on A549 cell activity and secretion in the constructed LPS-stimulated A549 cells model. On the designed microchip, a bubble trap chamber was designed to remove the bubbles in the culture medium which could also be simultaneously preheated by a split hot plate.
View Article and Find Full Text PDFHeliyon
May 2024
Department of Solid Mechanics, Faculty of Mechanical Engineering, University of Kashan, Kashan, P.O. Box 87317-53153, Iran.
Exp Parasitol
December 2024
University of Balamand, Faculty of Arts and Sciences, Lebanon.
Cutaneous leishmaniasis caused mainly by Leishmania major (L. major) is one of the trending models used to investigate induced hyperalgesia and the involved cytokines. Previous studies approached the role of several cytokines in the observed hyperalgesia, but the molecular mechanisms orchestrating such a response still needed to be addressed.
View Article and Find Full Text PDFLangmuir
December 2024
Department of Applied Chemistry, Faculty of Engineering Osaka Institute of Technology, 5-16-1 Omiya, Asahi-ku, Osaka 535-8585, Japan.
Hexagonal polymer plates of (sub)millimeter size that were uniform in shape and size were used as a stabilizer for emulsions, and the correlations of plate size, oil polarity, and plate dispersing media before emulsification with the formability, type, and droplet shape of emulsions were studied. The formability of the emulsions was improved by decreasing the plate size. The lower the oil polarity was, the more preferably O/W-type emulsions were formed, and as the oil polarity increased, the formability of W/O-type emulsions increased, whereas too high of an oil polarity resulted in no emulsion formation or macrophase separation of the oil dispersion of the plates and water.
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