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http://dx.doi.org/10.3390/jcm11195496 | DOI Listing |
Plants (Basel)
December 2024
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Flax is an important crop grown for seed and fiber. Flax chromosome number is 2n = 30, and its genome size is about 450-480 Mb. To date, the genomes of several flax varieties have been sequenced and assembled.
View Article and Find Full Text PDFJ Fungi (Basel)
December 2024
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia.
is a pathogenic fungus that infects flax and causes significant yield losses. In this study, we assembled the genomes of four highly virulent strains using the Oxford Nanopore Technologies (ONT, R10.4.
View Article and Find Full Text PDFMethods Mol Biol
November 2024
Faculty of Medicine, Department of Medicine I, Medical Center, University of Freiburg, Freiburg, Germany.
In order to sustain genomic stability by correct DNA replication and mitosis and thus avoid malignant transformation of cells, the cell cycle is a strictly regulated process. Aberrant cell cycle regulation and defects in mitosis in malignant cells are targets of various cancer therapies. Cancer cells may survive antimitotic treatment due to mitotic slippage with a residual activity of the ubiquitin ligase anaphase-promoting complex (APC/C) and a continuous slow ubiquitin-proteasome-dependent cyclin B-degradation leading to mitotic exit.
View Article and Find Full Text PDFEur J Haematol
January 2025
Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
High-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT) is widely used in patients with diffuse large B-cell lymphoma. HDCT/ASCT is associated with increased morbidity in elderly/unfit patients. We retrospectively evaluated the use of reduced intensity conditioning in DLBCL patients.
View Article and Find Full Text PDFNat Commun
July 2024
Research Institute for Systems Biology and Medicine, Moscow, 117246, Russian Federation.
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