ABCB1 belongs to a superfamily of membrane transporters that use ATP hydrolysis to efflux various endogenous compounds and drugs outside the cell. Cancer cells upregulate expression as an adaptive response to evade chemotherapy-mediated cell death. On the other hand, several reports highlight the role of the epigenetic regulation of expression. In fact, the promoter methylation of was found to be methylated in several tumor types, including gliomas, but its role as a biomarker is not fully established yet. Thus, the aim of this study was to analyze the methylation of the promoter in tumor tissues from 50 glioma patients to verify its incidence and to semi-quantitively detect methylation levels in order to establish its utility as a potential biomarker. The results of this study show a high interindividual variability in the methylation level of the samples derived from gliomas of different grades. Additionally, a positive correlation between methylation, the WHO tumor grade, and an wild-type status has been observed. Thus, methylation can be regarded as a potential diagnostic or prognostic biomarker for glioma patients, indicating more aggressive tumors.
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| http://dx.doi.org/10.3390/jcm11195655 | DOI Listing |
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