AI Article Synopsis

  • Protein-protein interactions (PPIs) are crucial for understanding cellular functions, leading to the development of various experimental and computational approaches for their identification.
  • The updated tool, UniReD, utilizes biomedical literature to identify known protein associations and predict potential new ones, enhancing research on PPIs.
  • UniReD allows users to input two lists of proteins—one related to a specific disease and another with potential associations—and it ranks the second list based on their relevance to the first, aiding in biomarker discovery and validation.

Article Abstract

Protein-protein interactions (PPIs) are of key importance for understanding how cells and organisms function. Thus, in recent decades, many approaches have been developed for the identification and discovery of such interactions. These approaches addressed the problem of PPI identification either by an experimental point of view or by a computational one. Here, we present an updated version of UniReD, a computational prediction tool which takes advantage of biomedical literature aiming to extract documented, already published protein associations and predict undocumented ones. The usefulness of this computational tool has been previously evaluated by experimentally validating predicted interactions and by benchmarking it against public databases of experimentally validated PPIs. In its updated form, UniReD allows the user to provide a list of proteins of known implication in, e.g., a particular disease, as well as another list of proteins that are potentially associated with the proteins of the first list. UniReD then automatically analyzes both lists and ranks the proteins of the second list by their association with the proteins of the first list, thus serving as a potential biomarker discovery/validation tool.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569535PMC
http://dx.doi.org/10.3390/ijms231911112DOI Listing

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