AI Article Synopsis
- Peptidoglycan recognition proteins (PGRPs) play a role in antibacterial responses in various animals, but their function in the giant triton snail is not well-studied.
- A new PGRP gene, Ct-PGRP-S1, was identified in the snail, showing key structural features and high expression levels mainly in the liver.
- Ct-PGRP-S1 demonstrated the ability to degrade peptidoglycan and exhibited antibacterial activity, indicating its significance in the snail's immune response against bacterial infections.
Article Abstract
Peptidoglycan recognition proteins (PGRPs) are a family of pattern recognition receptors (PRRs) involved in host antibacterial responses, and their functions have been characterized in most invertebrate and vertebrate animals. However, little information is available regarding the potential function of PGRPs in the giant triton snail . In this study, a short-type PGRP gene (termed ) was identified in . Ct-PGRP-S1 was predicted to contain several structural features known in PGRPs, including a typical PGRP domain (Amidase_2) and Src homology-3 (SH3) domain. The gene was constitutively expressed in all tissues examined except in proboscis, with the highest expression level observed in the liver. As a typical PRR, Ct-PGRP-S1 has an ability to degrade peptidoglycan (PGN) and was proven to have non-Zn-dependent amidase activity and antibacterial activity against and . It is the first report to reveal the peptidoglycan recognition protein in , and these results suggest that peptidoglycan recognition protein Ct-PGRP-S1 is an important effector of that modulates bacterial infection resistance of and , and this study may provide crucial basic data for the understanding of an innate immunity system of .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570181 | PMC |
| http://dx.doi.org/10.3390/ijms231911062 | DOI Listing |
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