Update in Molecular Testing for Intraocular Lymphoma.

Cancers (Basel)

Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.

Published: September 2022

The diagnosis of primary vitreoretinal lymphoma and central nervous system lymphoma is challenging. In cases with intraocular involvement, vitreous biopsy plays a pivotal role. Several diagnostic tests are employed to confirm a diagnosis and include cytologic evaluation, immunohistochemistry, flow cytometry, and cytokine analysis. The limitations of these conventional diagnostic tests stem from the often paucicellular nature of vitreous biopsy specimens and the fragility of malignant cells ex vivo. Several emerging molecular techniques show promise in improving the diagnostic yield of intraocular biopsy, possibly enabling more accurate and timely diagnoses. This article will review existing diagnostic modalities for intraocular lymphoma, with an emphasis on currently available molecular tests.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558525PMC
http://dx.doi.org/10.3390/cancers14194546DOI Listing

Publication Analysis

Top Keywords

intraocular lymphoma
8
vitreous biopsy
8
diagnostic tests
8
update molecular
4
molecular testing
4
intraocular
4
testing intraocular
4
lymphoma
4
lymphoma diagnosis
4
diagnosis primary
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!