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Post-craniotomy intracranial pressure monitoring: a novel approach combining optic nerve sheath diameter ultrasonography and cervical-cerebral arterial ultrasound.
Front Neurol
January 2025
Department of Ultrasound, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
Objective: Elevated intracranial pressure (ICP), a common complication in traumatic brain injuries (TBI), can lead to optic nerve sheath diameter (ONSD) enlargement and flow spectrum changes from the internal carotid artery (ICA) to middle cerebral artery (MCA). This study will investigate the use of Cervical-Cerebral Arterial Ultrasound (CCAU) for non-invasive ICP assessment and evaluating the related indices' clinical utility in TBI patients with decompressive craniotomy (DC).
Methods: ONSD and flow spectrum changes were measured within 24 h after DC in 106 patients via ultrasonic ONSD measurement and CCAU, simultaneously.
High-sensitivity flexible electrochemical sensor for real-time multi-analyte sweat analysis.
Talanta
January 2025
School of Material Science and Engineering, Shanghai University of Engineering Science, Shanghai, 201620, PR China. Electronic address:
Flexible sweat sensors play a crucial role in health monitoring and disease prevention by enabling real-time, non-invasive assessment of human physiological conditions. Sweat contains a variety of biomarkers, offering valuable insights into an individual's health status. In this study, we developed an advanced flexible electrochemical sensor featuring reduced graphene oxide (rGO)-based electrodes, modified with a composite material comprising nitrogen and sulfur co-doped holey graphene (HG) and MXene, with in-situ-grown TiO nanoparticles on the MXene.
View Article and Find Full Text PDFHigh-Conductivity, Self-Healing, and Adhesive Ionic Hydrogels for Health Monitoring and Human-Machine Interactions Under Extreme Cold Conditions.
Adv Sci (Weinh)
January 2025
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Ionic conductive hydrogels (ICHs) are emerging as key materials for advanced human-machine interactions and health monitoring systems due to their unique combination of flexibility, biocompatibility, and electrical conductivity. However, a major challenge remains in developing ICHs that simultaneously exhibit high ionic conductivity, self-healing, and strong adhesion, particularly under extreme low-temperature conditions. In this study, a novel ICH composed of sulfobetaine methacrylate, methacrylic acid, TEMPO-oxidized cellulose nanofibers, sodium alginate, and lithium chloride is presented.
View Article and Find Full Text PDFCharacterisation of sleep in a mouse model of CLN3 disease revealed sex-specific sleep disturbances.
J Sleep Res
January 2025
Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA.
The neuronal ceroid lipofuscinoses (NCLs) are a group of recessively inherited neurodegenerative diseases characterizsed by lysosomal storage of fluorescent materials. CLN3 disease, or juvenile Batten disease, is the most common NCL that is caused by mutations in the Ceroid Lipofuscinosis, Neuronal 3 (CLN3) gene. Sleep disturbances are among the most common symptoms associated with CLN3 disease that deteriorate the patients' life quality, yet this is understudied and has not been delineated in animal models of the disease.
View Article and Find Full Text PDFCharacterization of tumor epigenetic aberrations is integral to understanding the mechanisms of tumorigenesis and provide diagnostic, prognostic, and predictive information of high clinical relevance. Among the different tumor-associated epigenetic signatures, 5 methyl-cytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the two most well-characterized DNA methylation alterations linked to cancer pathogenesis. 5hmC has a tissue-specific distribution and its abundance is subjected to changes in tumor DNA, making it a promising biomarker.
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