Shortly before the DNA era began, PC Koller described lagging chromosomes and chromosome numerical abnormalities in human carcinomas. While present-day cancer geneticists would question some of Koller's conclusions, this study ultimately contributed to the realisation that chromosomal instability is a widespread feature of solid tumours.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938233 | PMC |
http://dx.doi.org/10.1038/s41416-022-01996-z | DOI Listing |
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