Acquired antibiotic resistance in bacteria has become an important worldwide challenge. Currently, several bacteria, including Escherichia coli, have multidrug resistance profiles. Genes such as bla CTX-M-24 and bla KPC-2 (carbapenemase) are widespread. This research letter reports about a genomic surveillance study where multidrug-resistant E. coli containing CTX-M-24(IncF [F-:A1:B32]) and KPC-2(IncX3/IncU) plasmids were obtained from community- acquired urinary tract infection in Brazil.
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http://dx.doi.org/10.1016/j.bjid.2022.102706 | DOI Listing |
Viruses
January 2025
Laboratory of Infectious Diseases, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
Self-assembling ferritin nanoparticle technology is a widely used vaccine development platform for enhancing the efficacy of subunit vaccines by displaying multiple antigens on nanocages. The dengue virus (DENV) envelope domain III (EDIII) protein, the most promising antigen for DENV, has been applied in vaccine development, and it is essential to evaluate the relative immunogenicity of the EDIII protein and EDIII-conjugated ferritin to show the efficiency of the ferritin delivery system compared with EDIII. In this study, we optimized the conditions for the expression of the EDIII protein in , protein purification, and refolding, and these optimization techniques were applied for the purification of EDIII ferritin nanoparticles.
View Article and Find Full Text PDFPharmaceutics
January 2025
Faculty of Pharmacy, "Grigore. T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Magnolol (MG) and honokiol (HK) are bioactive compounds extracted from and trees with significant pharmacological properties, including antioxidant and antibacterial activity. However, their poor water solubility and low bioavailability limit the therapeutic potential. To address these limitations, this study aims to develop MG and HK formulations by co-electrospinning using custom-synthesized β-cyclodextrin-oligolactide (β-CDLA) derivatives.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
Centre for Nanomaterials and Biotechnology, Faculty of Science, University of Jan Evangelista Purkyně, Pasteurova 15, 400 96 Ústí nad Labem, Czech Republic.
Surface modification of various polymer foils was achieved by UV activation and chemical grafting with cysteamine to improve surface properties and antimicrobial efficacy. UVC activation at 254 nm led to changes in surface wettability and charge density, which allowed the introduction of amino and thiol functional groups by cysteamine grafting. X-ray photoelectron spectroscopy (XPS) confirmed increased nitrogen and sulfur content on the modified surfaces.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
Department of Cosmetic and Biomaterials Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.
As the demand for sustainable and innovative solutions in food packaging continues to grow, this study endeavors to introduce a comprehensive exploration of novel active materials. Specifically, we focus on characterizing polylactide-poly(ethylene glycol) (PLA/PEG) films filled with olive leaf extract (OLE; ) obtained via solvent evaporation. Examined properties include surface structure, thermal degradation and mechanical attributes, as well as antibacterial activity.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
Division of Mechanical Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan 54538, Jeonbuk, Republic of Korea.
Bone tissue engineering aims to develop biomaterials that are capable of effectively repairing and regenerating damaged bone tissue. Among the various polymers used in this field, polycaprolactone (PCL) is one of the most widely utilized. As a biocompatible polymer, PCL is easy to fabricate, cost-effective, and offers consistent quality control, making it a popular choice for biomedical applications.
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