AI Article Synopsis
- Mucormycosis, a rare but serious fungal infection, primarily affects immunocompromised individuals and is caused by fungi from the Mucorales order.
- The infection can manifest in various ways, including sinusitis, skin issues, gastrointestinal problems, lung infections, and systemic spread.
- Treatment typically involves lipid formulations of amphotericin B as the standard approach, with surgical removal of infected tissue considered when possible, alongside ongoing research into new treatment options.
Article Abstract
Mucormycosis (previously called zygomycosis) is a serious but rare fungal infection caused by a group of fungi belonging to the order Mucorales. These molds exist throughout the environment and generally do not cause serious problems in humans. Mucormycosis mainly affects individuals who are immunocompromised. The clinical manifestations of mucormycosis are wide-ranging; they include sinusitis (pansinusitis, rhino-orbital, or rhino-cerebral) as well as cutaneous, gastrointestinal, pulmonary, and disseminate infections. Many uncertainties remain regarding how to control these infections despite the recent addition of triazoles to the antifungal arsenal for treating this infection. Currently, lipid formulations of amphotericin B have become the standard treatment for mucormycosis due to their efficiency. Moreover, a growing body of data supports the need for surgical excision of infected and/or necrosed tissue whenever practical. In this mini review, the current status of treatment options for mucormycosis and recent studies of novel therapeutic options will be presented.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560507 | PMC |
| http://dx.doi.org/10.1371/journal.ppat.1010858 | DOI Listing |
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