Control of self-propelled particles is central to the development of many microrobotic technologies, from dynamically reconfigurable materials to advanced lab-on-a-chip systems. However, there are few physical principles by which particle trajectories can be specified and can be used to generate a wide range of behaviors. Within the field of ray optics, a single principle for controlling the trajectory of light─Snell's law─yields an intuitive framework for engineering a broad range of devices, from microscopes to cameras and telescopes. Here we show that the motion of self-propelled particles gliding across a resistance discontinuity is governed by a variant of Snell's law, and develop a corresponding ray optics for gliders. Just as the ratio of refractive indexes sets the path of a light ray, the ratio of resistance coefficients is shown to determine the trajectories of gliders. The magnitude of refraction depends on the glider's shape, in particular its aspect ratio, which serves as an analogue to the wavelength of light. This enables the demixing of a polymorphic, many-shaped, beam of gliders into distinct monomorphic, single-shaped, beams through a friction prism. In turn, beams of monomorphic gliders can be focused by spherical and gradient friction lenses. Alternatively, the critical angle for total internal reflection can be used to create shape-selective glider traps. Overall our work suggests that furthering the analogy between light and microscopic gliders may be used for sorting, concentrating, and analyzing self-propelled particles.
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http://dx.doi.org/10.1021/acsnano.2c05015 | DOI Listing |
Nat Commun
December 2024
Department of Ophthalmology, Columbia University, New York, NY, USA.
Best1 and Best2 are two members of the bestrophin family of anion channels critically involved in the prevention of retinal degeneration and maintenance of intraocular pressure, respectively. Here, we solved glutamate- and γ-aminobutyric acid (GABA)-bound Best2 structures, which delineate an intracellular glutamate binding site and an extracellular GABA binding site on Best2, respectively, identified extracellular GABA as a permeable activator of Best2, and elucidated the co-regulation of Best2 by glutamate, GABA and glutamine synthetase in vivo. We further identified multiple small molecules as activators of the bestrophin channels.
View Article and Find Full Text PDFRev Sci Instrum
December 2024
X-ray Astrophysics Laboratory, NASA Goddard Space Flight Center, Greenbelt, Maryland 20771, USA.
This paper presents progress made toward the overarching goal to adapt single-photon-counting microcalorimeters to magnetic fusion energy research and demonstrate the value of such measurements for fusion. Microcalorimeter spectrometers combine the best characteristics of x-ray instrumentation currently available on fusion devices: high spectral resolution similar to an x-ray crystal spectrometer and broad spectral coverage sufficient to measure impurity species from Be to W. As a proof-of-principle experiment, a NASA-built x-ray microcalorimeter spectrometer has been installed on the Madison Symmetric Torus (MST) at the Wisconsin Plasma Physics Laboratory.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2024
Department of Physics, RTM Nagpur University, Nagpur 440033, India.
While searching for a new host suitable for near infrared (NIR) emission, we explored a new composition NaLaMgWO. The samples were prepared by solid state reaction method. X-ray Diffraction confirms crystallization of NaLaMgWO in monoclinic system.
View Article and Find Full Text PDFDent Mater
December 2024
Graduate Program in Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre 2492, Brazil; Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre 2492, Brazil. Electronic address:
Objectives: To evaluate the self-etch bonding potential of universal adhesive systems with varying acidic compositions by analyzing the wettability properties, topographical change, and microshear bond strength (µSBS) to enamel.
Methods: Eight universal adhesives were tested: All-Bond Universal (Bisco), Ambar Universal (FGM), Gluma Bond Universal (Kulzer), OptiBond Universal (Kerr), Peak Universal Bond (Ultradent), Prime&Bond Universal (Dentsply), Singlebond Universal (3 M ESPE), and Tetric N-Bond Universal (Ivoclar). Bovine incisors were prepared and treated with each adhesive according to the manufacturer's instructions.
Vaccine
December 2024
F.I. Proctor Foundation, University of California, San Francisco, California, United States; Department of Ophthalmology, University of California, San Francisco, California, United States; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States. Electronic address:
Background: Herpes zoster is a potential risk factor for dementia. The effectiveness of the recombinant zoster vaccine for preventing dementia is uncertain.
Methods: This retrospective cohort study used de-identified claims data from the Optum Labs Data Warehouse database from January 1, 2017, to December 31, 2022, to determine whether the recombinant zoster vaccine is associated with a reduced risk of dementia.
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