Background: Technically and ergonomically correct positioning is essential in endoscopic transsphenoidal pituitary surgery.
Objective: To propose a safe, ergonomic approach to conduct endoscopic endonasal pituitary and skull base surgery in large patients without sacrificing important aspects of current standard practice.
Methods: The patient's right arm is outstretched and secured in a supine position, with the primary surgeon standing in the axillary area. Considerations include maintaining comfort, immobility, anesthesia access, endotracheal tube fixation, intravenous lines, thorax elevated 25° to 30° for optimization of respiration, free and exposed abdomen for fat graft, legs positioned with no sciatic stretch or venous strain, and the patient's head in parallel with the surrounding area to sustain a strict midline.
Results: Ten patients who underwent transsphenoidal pituitary tumor resections conducted using the hitchhiker position from October 2019 to June 2021 comprised our study cohort. The patients' mean height was 168.70 ± 9.29 cm, their mean weight was 114.35 ± 19.32 kg, and their mean body mass index was 40.19 ± 6.39 kg/m 2 . Twenty percent (n = 2) patients had a body mass index classified as "obesity class 1," 50% (n = 5) as "obesity class 2," and 30% (n = 3) as "extreme obesity class 3." The primary surgeon consistently reported decreased bodily strain and improved ergonomic access to the surgical site using the hitchhiker position.
Conclusion: The hitchhiker position offers the opportunity to improve both patient and physician well-being in the context of endoscopic pituitary surgery.
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http://dx.doi.org/10.1227/ons.0000000000000363 | DOI Listing |
Plasmid
July 2023
Laboratoire de Microbiologie et de Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Centre National de la Recherche Scientifique, Université de Toulouse, UPS, Toulouse F-31000, France. Electronic address:
Plasmid families harbor different maintenances functions, depending on their size and copy number. Low copy number plasmids rely on active partition systems, organizing a partition complex at specific centromere sites that is actively positioned using NTPase proteins. Some low copy number plasmids lack an active partition system, but carry atypical intracellular positioning systems using a single protein that binds to the centromere site but without an associated NTPase.
View Article and Find Full Text PDFOper Neurosurg (Hagerstown)
November 2022
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Background: Technically and ergonomically correct positioning is essential in endoscopic transsphenoidal pituitary surgery.
Objective: To propose a safe, ergonomic approach to conduct endoscopic endonasal pituitary and skull base surgery in large patients without sacrificing important aspects of current standard practice.
Methods: The patient's right arm is outstretched and secured in a supine position, with the primary surgeon standing in the axillary area.
Theor Popul Biol
December 2021
Faculty of Technology, Bielefeld University, Postbox 100131, 33501 Bielefeld, Germany. Electronic address:
Recently, the selection-recombination equation with a single selected site and an arbitrary number of neutral sites was solved by Alberti and Baake (2021) by means of the ancestral selection-recombination graph. Here, we introduce a more accessible approach, namely the ancestral initiation graph. The construction is based on a discretisation of the selection-recombination equation.
View Article and Find Full Text PDFEMBO Rep
March 2021
Division of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Centre, Leiden, The Netherlands.
The endoplasmic reticulum (ER) is the largest organelle contacting virtually every other organelle for information exchange and control of processes such as transport, fusion, and fission. Here, we studied the role of the other organelles on ER network architecture in the cell periphery. We show that the co-migration of the ER with other organelles, called ER hitchhiking facilitated by late endosomes and lysosomes is a major mechanism controlling ER network architecture.
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