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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Exeter, Exeter, Devon, United Kingdom.
Background: Psychosis (broadly delusions and hallucinations) has a cumulative disease prevalence of around 40% in Alzheimer's disease (AD). The epigenomic, genomic, and neuropathological data provide powerful evidence that AD+P has a distinct neurobiological profile. Here, we used the weighted gene co-expression network analysis (WGCNA) method to investigate DNA methylation associated with AD+P in the dorsolateral prefrontal cortex of 153 post-mortem brain samples.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Norwegian University of Science and Technology, Trondheim, Norway.
Background: Accumulation of oxidative DNA damage and its inefficient repair is a contributing factor to Alzheimer's disease (AD), yet the underlying mechanism remains largely unknown. Novel AD mouse models deficient for oxidative DNA damage repair were developed and characterized to better understand their impact on AD progression. In addition, vascularized cerebral organoids from AD patients were generated to translate findings to a human model of AD.
View Article and Find Full Text PDFCurvilinear incidence models for parity in the entire fertility range for cancers of the breast, ovary, and endometrium: A follow-up of the Norwegian 1960 Census.
Int J Cancer
January 2025
Administration, Norwegian Computing Center, Oslo, Norway.
The protective effect of parity has been demonstrated for cancer of the breast, ovary, and endometrium but no studies have estimated the effect of each subsequent birth in women with 10 or more children or grand-grand parity women, nor compared the linear relationship of the three cancers sites. Here, we aim to explore these relationships based on the Norwegian 1960 Census. The question of parity in present marriage was answered by 385,816 women born 1870-1915, a period with high fertility.
View Article and Find Full Text PDFPre-diagnostic 25-hydroxyvitamin D levels and subsite-specific colorectal cancer risk: A nested case-control study from the Norwegian Women and Cancer Study (NOWAC).
Br J Nutr
January 2025
Department of Community Medicine, University of Tromsø - The Arctic University of Norway, 9037 Tromsø, Norway.
Colorectal cancer, the third most common cancer globally, causes over 900,000 deaths annually. Although vitamin D is observed to have potential anti-carcinogenic properties, research findings on its preventable effect against colorectal cancer remain inconclusive. Notably, different subsites within the colon and rectum may be associated with distinct risk factors.
View Article and Find Full Text PDFHuman Footprint and Forest Disturbance Reduce Space Use of Brown Bears (Ursus arctos) Across Europe.
Glob Chang Biol
January 2025
Biotechnical Faculty, Department of Biology, University of Ljubljana, Ljubljana, Slovenia.
Three-quarters of the planet's land surface has been altered by humans, with consequences for animal ecology, movements and related ecosystem functioning. Species often occupy wide geographical ranges with contrasting human disturbance and environmental conditions, yet, limited data availability across species' ranges has constrained our understanding of how human pressure and resource availability jointly shape intraspecific variation of animal space use. Leveraging a unique dataset of 758 annual GPS movement trajectories from 375 brown bears (Ursus arctos) across the species' range in Europe, we investigated the effects of human pressure (i.
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