Presented herein is a streamlined synthesis of building blocks of a rare sugar D-altrosamine. Also investigated was the glycosylation of different glycosyl acceptors with differentially protected altrosamine donors. High facial stereoselectivity was achieved with 3--picoloyl donors and reactive glycosyl acceptors the H-bond-mediated aglycone delivery (HAD) pathway. In contrast, glycosidations of the altrosamine donor equipped with the 3--benzoyl group were poorly stereoselective.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548543 | PMC |
| http://dx.doi.org/10.3389/fchem.2022.945779 | DOI Listing |
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