Turnaround time (TAT), which doctors frequently use as the benchmark for laboratory performance, is a typical way to communicate timeliness. It also acts as a quality indicator to evaluate the effectiveness and efficiency of the testing process and the satisfaction of clinicians and patients. TAT is the time from receipt of the sample in the laboratory to final delivery or dispatch of the report of said test. The TAT procedure can be broadly divided into three stages pre-analytical, analytical and post-analytical. There is variability in TAT according to different conditions like the volume of sample size, staff expertise, availability of adequate resources, distances of the hospital from the lab, and various sub-departments. To remove obstacles to optimizing TAT, we must take a practical approach. A workload reduction plan, proper stock management, specialized work assignments, and skilled staff retention are crucial strategies to reduce the setting's delayed TAT.
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http://dx.doi.org/10.7759/cureus.28824 | DOI Listing |
BioTech (Basel)
January 2025
Valent BioSciences, Biorational Research Center, 1910 Innovation Way, Suite 100, Libertyville, IL 60048, USA.
Organisms from the genus feature actinobacteria with complex developmental cycles and a great ability to produce a variety of natural products. These soil bacteria produce more than 2/3 of antibiotics used in medicine, and a large variety of bioactive compounds for industrial, medical and agricultural use. Although spp.
View Article and Find Full Text PDFPLoS One
January 2025
IBM Research, Rio de Janeiro, Brazil.
For optimizing production yield while limiting negative environmental impact, sustainable agriculture benefits from real-time, on-the-spot chemical analysis of soil at low cost. Colorimetric paper sensors are ideal candidates, however, their automated readout and analysis in the field is needed. Using mobile technology for paper sensor readout could, in principle, enable the application of machine-learning models for transforming colorimetric data into threshold-based classes that represent chemical concentration.
View Article and Find Full Text PDFSci Rep
January 2025
Faculty of Allied Health Sciences, Center of Excellence for Innovative Diagnosis of Antimicrobial Resistance, Chulalongkorn University, Bangkok, 10330, Thailand.
Rifampicin-resistant tuberculosis (RR-TB) is a critical issue with significant implications for patient care, public health, and TB control efforts that necessitate comprehensive strategies for detection. This study presents a novel point-of-care diagnostic tool for RR-TB detection employing a peptide nucleic acid (PNA)-paper-based sensor combined with isothermal recombinase polymerase amplification (RPA). The sensor targets mutations in codons 516, 526, and 531 of the rpoB gene, the top three common mutations associated with rifampicin-resistant strains.
View Article and Find Full Text PDFAJNR Am J Neuroradiol
January 2025
From the Tu Lab for Diagnostic Research, Yale School of Medicine, New Haven, CT, USA (OAZ, AEK, SR) and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (IDOS, JJ, LHT).
Background And Purpose: Timely reporting of CTA exams impacts management of acute vascular pathology such as large vessel occlusions, arterial dissection, and ruptured aneurysm as well as a variety of acute non-vascular pathologies. In this study, we examine potential modifiable factors impacting the timeliness of CTA reporting performed in stroke code activations.
Materials And Methods: Observational study of stroke code CTA head and neck exams performed at a single health system (3 emergency departments, 1550 inpatient beds) over four years (1/1/2019-12/31/2023).
J Infect Dis
January 2025
Department of Pulmonary and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, P.R. China.
Background And Objective: Multiplex polymerase chain reaction (PCR)-based targeted next-generation sequencing (tNGS) is a promising tool for distinguishing lower respiratory tract infections (LRTIs) in clinical practice, and its detectable pathogen spectrum can cover more than 95% of clinical cases. but there is limited information on systematic evaluation of the clinical use of multiplex PCR-based tNGS (mp-tNGS) in IPA cases. We aim to assess mp-tNGS in bronchoalveolar lavage fluid (BALF) for Aspergillus detection in suspected IPA patients, and to provide a reliable basis for initiating antifungal therapy without microbiological or histopathological evidence.
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