Herein, we propose a coupled Jaynes-Cummings model for the preparation of strong antibunched single photons and antibunched correlated photon pairs. Using the effective Hamiltonian method, we obtained the expression for the correlation function and then presented the optimal conditions for conventional/unconventional photon blockade. The results showed that on one hand, an intersection point exists between conventional photon blockade and unconventional photon blockade and that the performance of the single photon at the intersection point is better. On the other hand, under the condition of unconventional photon blockade, the photons produced by each Jaynes-Cummings system are strongly correlated with each other.
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http://dx.doi.org/10.1364/OE.460503 | DOI Listing |
Nanophotonics
January 2025
Institute of Physics, Swiss Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Sum-frequency generation (SFG) enables the coherent upconversion of electromagnetic signals and plays a significant role in mid-infrared vibrational spectroscopy for molecular analysis. Recent research indicates that plasmonic nanocavities, which confine light to extremely small volumes, can facilitate the detection of vibrational SFG signals from individual molecules by leveraging surface-enhanced Raman scattering combined with mid-infrared laser excitation. In this article, we compute the degree of second order coherence ( (0)) of the upconverted mid-infrared field under realistic parameters and accounting for the anharmonic potential that characterizes vibrational modes of individual molecules.
View Article and Find Full Text PDFJ Control Release
January 2025
College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:
The interaction between programmed death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) constitutes a critical immune checkpoint pathway that leads to immune tolerance in cancer cells and impacts antitumor treatment. Monoclonal antibody blockade of the PD-L1 immunoinhibitory pathway has demonstrated significant and lasting clinical antitumor responses. Furthermore, PD-L1 serves as an important biomarker for predicting the effectiveness of immune checkpoint inhibitors (ICIs).
View Article and Find Full Text PDFBioconjug Chem
January 2025
Canary Center for Cancer Early Detection, Department of Radiology, Stanford University, Palo Alto, California 94304, United States.
The interaction between cancer cells and immune cells in the tumor microenvironment (TME) plays a crucial role in determining tumor growth, metastasis, and response to treatment. Tumor-infiltrating lymphocytes (TILs) in TME could be a predictive marker for treatment response in various therapeutic interventions, including chemotherapy and immunotherapy. Thus, imaging the tumor immune microenvironment is important for selecting the optimal treatment strategies in cancer therapy.
View Article and Find Full Text PDFMater Today Bio
December 2024
Key Laboratory of Molecular Cytogenetics and Genetic Breeding of Heilongjiang Province, College of Life Science and Technology, Harbin Normal University, Harbin, 150025, China.
Immunotherapy based on immune checkpoint blockade has emerged as a promising treatment strategy; however, the therapeutic efficacy is limited by the immunosuppressive microenvironment. Here, we developed a novel immune-activated nanoparticle (Fc-SS-Fe/Cu) to address the issue of insufficient immune infiltration. Specifically, the structure of Fc-SS-Fe/Cu collapsed in response to the tumor microenvironment, the ferrocene and disulfide bonds and the released Fe/Cu ions can effectively generate ·OH and deplete GSH to increase oxidative stress, thereby inducing ferroptosis.
View Article and Find Full Text PDFWe have achieved a conventional photon blockade and two-photon blockade in a second-order nonlinear system with a two-level atom embedded in a high-frequency cavity. The physical mechanisms behind the implementation of both types of photon blockade are explained, and analytical conditions for achieving a conventional photon blockade are derived, which are consistent with the numerical solutions of the master equation in the steady-state limit. By appropriately setting the system parameters, we can achieve simultaneous conventional photon blockade in the high-frequency cavity and two-photon blockade in the low-frequency cavity.
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