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Excitation-Wavelength-Dependent Functionalities of Temporally Controlled Sensing and Generation of Singlet Oxygen by a Photoexcited State Engineered Rhodamine 6G-Anthracene Conjugate. | LitMetric

AI Article Synopsis

  • - The study presents a new molecule, RA, which can sense and generate singlet oxygen (O) and has various functions depending on the wavelength of light used.
  • - RA behaves like a traditional O sensor when exposed to UV-visible light, similar to a commercial product called SOSG, and can also operate as a delayed O sensor under longer wavelengths (~700 nm).
  • - Additionally, RA effectively generates O when exposed to green light, showing potential as a therapeutic agent against pancreatic cancer by targeting the cells specifically.

Article Abstract

The present study provides design guidance for unique multipotent molecules that sense and generate singlet oxygen ( O ). A rhodamine 6G-aminomethylanthracene-linked donor-acceptor molecule (RA) is designed and synthesized for demonstrating wavelength-dependent functionalities as follows; (i) RA acts as a conventional fluorogenic O sensor molecule like the commercially available reagent, singlet oxygen sensor green (SOSG), when it absorbs ultraviolet (UV)-visible light and reacts with O . (ii) RA acts as a temporally controlled O sensing reagent under the longer wavelength (∼700 nm) photosensitization. RA enters an intermediate state after capturing O and does not become strongly fluorescent until it is exposed to UV, blue, or green light. (iii) RA acts as an efficient photosensitizer to generate O under green light illumination. The spin-orbit charge transfer mediated intersystem crossing (SOCT-ISC) process achieves this function, and RA shows a potential cancer-killing effect on pancreatic cancer cells. The wavelength-switchable functionalities in RA offer to promise molecular tools to apply O in a spatiotemporal manner.

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http://dx.doi.org/10.1002/chem.202202014DOI Listing

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