and Alleles are Associated with Acitretin Response in Patients with Psoriasis.

Background: Psoriasis vulgaris is an immune-mediated inflammatory skin disease. Although the pathogenesis of psoriasis is unclear, genetic susceptibility, such as , is believed to be a major risk factor. However, there is a paucity of knowledge regarding the relationship between genetics and the response to systemic treatment of psoriasis. We hypothesized that genetic variations in human leukocyte antigen () genes may act as predictors of acitretin treatment in psoriasis. The aim of our study was to explore the presence of gene variants in patients with moderate-to-severe psoriasis receiving acitretin treatment.

Methods: A total of 100 Han Chinese patients with psoriasis completed the study. 24 patients including 16 responders and 8 non-responders underwent deep sequencing by MHC targeted region capture and 76 samples were genotyped by Sanger sequencing (SBT) based typing for validation.

Results: Regressions with adjustment for age, sex, body mass index (BMI), and baseline psoriasis area and severity index (PASI) revealed that two alleles (, ) were associated with the response to acitretin. The -positive patients showed a better response to acitretin compared to the -negative patients (relative risk (RR) = 10.34, 95% confidence interval (CI): 2.62-40.77, = 0.001), and the -positive patients manifested a better response to acitretin when compared to the -negative patients (RR = 21.01, 95% CI: 2.53-174.27, = 0.005).

Conclusions: Our observations support the potential role of and as pharmacogenetic markers of the acitretin response in patients with psoriasis.