Exploring vast microbial epitope spaces.

Immunity

Center for Regenerative Therapies, Technische Universität (TU) Dresden, 01307 Dresden, Germany; Department of Medicine I, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany. Electronic address:

Published: October 2022

The spectrum and origin of commensal bacterial HLA epitopes is not well understood. In this issue of Immunity, Pedersen et al. provide a systematic analysis of commensal bacterial HLA II epitopes and demonstrate plasticity of corresponding CD4 T cell responses.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2022.09.010DOI Listing

Publication Analysis

Top Keywords

commensal bacterial
8
bacterial hla
8
hla epitopes
8
exploring vast
4
vast microbial
4
microbial epitope
4
epitope spaces
4
spaces spectrum
4
spectrum origin
4
origin commensal
4

Similar Publications

Background: Sponges harbor microbial communities that play crucial roles in host health and ecology. However, the genetic adaptations that enable these symbiotic microorganisms to thrive within the sponge environment are still being elucidated. To understand these genetic adaptations, we conducted a comparative genomics analysis on 350 genomes of Actinobacteriota, a phylum commonly associated with sponges.

View Article and Find Full Text PDF

While Drosophila melanogaster serves as a crucial model for investigating both the circadian clock and gut microbiome, our understanding of their relationship in this organism is still limited. Recent analyses suggested that the Drosophila gut microbiome modulates the host circadian transcriptome to minimize rapid oscillations in response to changing environments. Here, we examined the composition and abundance of the gut microbiota in wild-type and arrhythmic per flies, under 12 h:12 h light: dark (12:12 LD) and constant darkness (DD) conditions.

View Article and Find Full Text PDF

Cell wall components of gut commensal bacteria stimulate peritrophic matrix formation in malaria vector mosquitoes through activation of the IMD pathway.

PLoS Biol

January 2025

State Key Laboratory of Genetic Engineering, School of Life Sciences, Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

The peritrophic matrix (PM) acts as a physical barrier that influences the vector competence of mosquitoes. We have previously shown that gut microbiota promotes PM formation in Anopheles stephensi, although the underlying mechanisms remain unclear. In this study, we identify that the cell wall components of gut commensal bacteria contribute to PM formation.

View Article and Find Full Text PDF

Particulate air pollutants, a major air pollution component, are detrimental to human health and a significant risk to wildlife and ecosystems globally. Here we report the effects of particulate pollutant black carbon on the beneficial gut microbiome of important global insect pollinator, the buff-tailed bumblebee (Bombus terrestris). Our data shows that exposure to black carbon particulates alters biofilm structure, gene expression and initial adhesion of beneficial bee gut coloniser, Snodgrassella alvi.

View Article and Find Full Text PDF

The community dynamic alterations mechanisms of traveling plastics in the Pearl River estuary with the salinity influence.

Water Res

December 2024

College of Environment and Energy, South China University of Technology, Guangzhou 510006, China; The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education, Guangzhou 510006, China. Electronic address:

Most ocean plastics originate from terrestrial emissions, and the plastisphere on the plastics would alter during the traveling due to the significant differences in biological communities between freshwater and marine ecosystems. Microorganisms are influenced by the increasing salinity during traveling. To understand the contribution of plastic on the alteration in biological communities of plastisphere during traveling, this study investigated the alterations in microbial communities on plastics during the migration from freshwater to brackish water and saltwater.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!