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Tetrazolium-based colorimetric assays underestimat the direct antitumor effects of anti-VEGF agent bevacizumab.
Toxicol In Vitro
September 2023
Department of Immunology, Zhuhai Campus of Zunyi Medical University, 519040 Zhuhai, China. Electronic address:
The direct antitumor effect of bevacizumab (BEV) has long been debated. Assessment of the direct cytotoxic activities of drugs is usually conducted via in vitro experiments, of which tetrazolium-based colorimetric assays are widely employed to measure the direct antitumor activity of BEV. This study aimed to investigate whether tetrazolium-based colorimetric assays are applicable when evaluating the cytotoxicity of BEV against tumor cells.
View Article and Find Full Text PDFA fast Resazurin-based live viability assay is equivalent to the MTT-test in the KeratinoSens assay.
Toxicol In Vitro
June 2015
Givaudan Schweiz AG, Ueberlandstrasse 138, CH-8600 Duebendorf, Switzerland. Electronic address:
The KeratinoSens™ assay was the first cell-based in vitro test in the skin sensitisation adverse outcome pathway to be endorsed by an ECVAM statement. It includes a cell viability assessment, which serves two purposes: It forms part of the prediction model to exclude false-positive irritants and cytotoxicity provides some information on sensitizer potency of chemicals, which can feed into a multivariate potency model. In the KeratinoSens™ protocol, Nrf2-dependent luciferase induction and the MTT-viability assay are performed in parallel plates.
View Article and Find Full Text PDFMicrophotometric determination of structure-bound oxidoreductase activities avoiding nothing-dehydrogenase artefacts: succinate dehydrogenase.
Histochem Cell Biol
August 1997
Fakultät für Biologie, Universität Konstanz, Germany.
A tetrazolium-based microphotometric method has been devised for the determination of structure-bound dehydrogenase activities with correction for nothing-dehydrogenase artefacts. The method is based on the microphotometric recording of maximum reaction rates in a simple incubation chamber and consists of two successive measurements on the same section, the first in the absence and the second in the presence of the substrate. Following the first measurement, the substrate-free medium is quickly exchanged with the substrate-containing medium and a second measurement is taken.
View Article and Find Full Text PDFPreliminary evaluation of Biolog, a carbon source utilization method for bacterial identification.
J Clin Microbiol
June 1991
Centers for Disease Control, Atlanta, Georgia 30333.
The Biolog Identification System (Biolog, Inc., Hayward, Calif.) is a new bacterial identification method that establishes an identification based on the exchange of electrons generated during respiration, leading to a subsequent tetrazolium-based color change.
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