Objective: This study aimed to estimate the disc status in intermittent closed lock (ICL) and permanent closed lock (CL) temporomandibular disorders (TMDs) to test the hypothesis that the disc morphology and degree of anterior disc displacement affect the outcomes of these disorders.
Materials And Methods: All patients were clinically examined according to the Diagnostic Criteria for Temporomandibular Disorders Axis I protocol, and magnetic resonance imaging (MRI) confirmed ICL and CL. Fifty-six joints of 56 patients with ICL and 110 joints of 110 patients with acute CL with a locking period of less than 3 months were included. Patients with acute CL were further classified into two groups: those with CL that could be successfully manipulated (CLs group) and those with acute CL without the possibility of unlocking (CLu group). MRI was used to assess the degree of anterior displacement, lateral displacement of the disc, disc deformity, and joint effusion. MRI findings were compared among the joints in the ICL, CLs, and CLu groups.
Results: The degree of anterior displacement and disc deformity prevalence significantly differed among the ICL, CLs, and CLu groups. No significant intergroup differences were observed in terms of lateral displacement or joint effusion.
Conclusions: These results suggest that anteriorly displaced discs and deformation of discs associated with TMD progression affect disc reducibility.
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http://dx.doi.org/10.1007/s11282-022-00659-2 | DOI Listing |
bioRxiv
December 2024
Istanbul Medipol University, School of Engineering and Natural Sciences, Department of Biomedical Engineering, 34810, Istanbul, Turkey.
G protein-coupled receptor (GPCR) signaling is terminated by arrestin binding to a phosphorylated receptor. Binding propensity has been shown to be modulated by stabilizing the pre-activated state of arrestin through point mutations or C-tail truncation. Here, we hypothesize that pre-activated rotated states can be stabilized by small molecules, and this can promote binding to phosphorylation-deficient receptors, which underly a variety of human disorders.
View Article and Find Full Text PDFJ Craniofac Surg
December 2024
Oral and Maxillofacial Radiology, Ain Shams University. Oral and Maxillofacial Radiology, Badr University in Cairo.
Purpose: This study aimed at comparing the therapeutic effect of nalbuphine in comparison to morphine after Temporomandibular joint (TMJ) arthrocentesis in patients with anterior disc displacement without reduction (ADDwoR).
Materials And Methods: Twenty-four female patients diagnosed with ADDwoR. Patients were treated with TMJ arthrocentesis then randomly divided into parallel groups.
mSphere
January 2025
Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Unlabelled: Bacterial pathogens remain poorly characterized in bats, especially in North America. We describe novel (and in some cases panmictic) hemoplasmas (10.1% positivity) and bartonellae (25.
View Article and Find Full Text PDFJ Clin Orthop Trauma
December 2024
Department of Orthopaedic and Trauma Surgery Department, British Hospital of Buenos Aires, Buenos Aires Argentina, Perdriel 74, C1280 AEB, Buenos Aires, Argentina.
Background: Although the intramedullary nail represents the treatment for most tibia diaphyseal fractures, there is no agreement on the configuration of the distal locking screws. Therefore, this study aimed to investigate the impact of the configuration of distal locking bolts on the healing of a tibial shaft fracture.
Methods: We retrospectively analyzed 170 closed fractures of the tibia diaphyseal operated consecutively between 2018 and 2021.
Front Neuroinform
November 2024
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany.
We introduce an open-source Python package for the analysis of large-scale electrophysiological data, named SyNCoPy, which stands for Systems Neuroscience Computing in Python. The package includes signal processing analyses across time (e.g.
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