AI Article Synopsis
- The study aimed to assess how thyroid function biomarkers fluctuate throughout the day in healthy individuals to aid in timely diagnosis of thyroid disorders.
- Blood samples from 31 participants were taken at six different times during the day to measure levels of key thyroid hormones and analyzed for variation patterns.
- Results indicated that males had higher levels of all measured hormones compared to females, with TSH showing a clear peak at midnight, emphasizing the need for time-specific sampling in clinical evaluations.
Article Abstract
Objective: We evaluated the intraday changes of thyroid function biomarkers in healthy subjects to help clinicians diagnose thyroid diseases in appropriate timing.
Methods: Blood samples were collected from 31 subjects at 0:00, 4:00, 8:00, 12:00, 16:00 and 20:00 on the sampling day and analyzed for thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), and free T4 (FT4). The intraday concentration changes were analyzed using Friedman's 2-way analysis of variance by ranks.
Results: The concentrations of TSH, T3, T4, FT3, and FT4 in males were significantly higher than those in females (P < .01). The obvious peak circadian rhythm of TSH was observed at 0:00 AM with gradual decline thereafter, whereas other biomarkers showed no rhythmic changes.
Conclusion: Sex differences should be considered in interpreting thyroid function tests. It is important to select the sampling time according to the clinician's diagnostic needs, especially at night when TSH secretion peaks.
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| http://dx.doi.org/10.1093/labmed/lmac105 | DOI Listing |
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