Seborrheic keratosis is a benign epidermal tumor. Seborrheic keratosis with clonal pattern (CPSK) displays histologic features distinct from other subtypes of SK (non-CPSK). We sought to quantitatively assess the risk of recurrence and progression to squamous cell carcinoma (SCC), either in situ or invasive, of incompletely excised CPSKs. We studied all 244 cases from 238 patients of "seborrheic keratosis, clonal pattern" diagnosed in our institution over a 10-year period (2008-2018). Demographic, clinical, pathologic, and follow-up data were gleaned from electronic health records. Following glass slide review, CPSK lesions were divided into 2 groups: CPSK with cytologic atypia and CPSK without cytologic atypia. For comparison, 107 non-CPSKs were studied as controls. The minimum follow-up period was 2 years (median=4 y). All lesions were incompletely excised. Eighteen of 244 CPSKs (7.4%) recurred at or adjacent to the site of initial partial removal compared with 1.9% of non-CPSKs. Five of the 18 (28%) recurrent CPSKs recurred as CPSK, 11 (61%) as SCC in situ, and 3 (17%) as invasive SCC. The mean time to recurrence was 3.1 years. Two non-CPSKs recurred as non-CPSKs. Overall CPSKs were more likely to recur than non-CPSKs ( P =0.04). CPSKs with atypia were more likely to recur than CPSKs without atypia ( P =0.03). The upgrade rate to SCC at least in situ of all recurrent CPSK lesions with atypia was 78%. Our results suggest that pathologists should report the presence of clonal pattern when observed in seborrheic keratoses, indicate the presence of atypia, and provide lesional margin assessment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/PAS.0000000000001973 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A rare case of pigmented seborrhoeic keratosis of scalp.
Med J Malaysia
January 2025
Department of General Surgery, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Thandalam, Chennai, Tamil Nadu, India.
Seborrheic keratosis (SK) is a prevalent hyperkeratotic dermatological condition characterized by benign proliferation of epidermal keratinocytes, typically occurring in the middle to advanced stages of life. While the trunk is the primary site for lesions, they can also manifest on the extremities, face, and scalp. Although SK is typically benign, there can be morphological overlap with malignant skin lesions, necessitating meticulous differentiation for an accurate diagnosis.
View Article and Find Full Text PDFPrimary Systemic Amyloidosis Characterized by Multiple Keratinous Cysts: A Case Report.
J Cutan Pathol
December 2024
Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Article Synopsis
- A 67-year-old male presented with skin plaques and bruising on the neck and hands for 2 years, along with nail issues.
- Histopathological tests indicated the presence of keratinous cysts and eosinophilic material, which tested positive for Congo red staining.
- A bone marrow biopsy confirmed multiple myeloma, leading to a diagnosis of primary systemic amyloidosis alongside multiple myeloma.
Identification of Associations with Dermatologic Diseases through a Focused GWAS of the UK Biobank.
JID Innov
January 2025
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Article Synopsis
- The UK Biobank contains genotype data for around 500,000 individuals and over 7,000 traits, but many significant relationships are overlooked due to the vast number of tests conducted.
- This study focuses on 13 skin-related conditions and identifies 447 important genetic variants that are more likely to affect protein functions, along with a higher CADD score, indicating their potential impact.
- Through further analysis, the researchers not only confirmed existing pathways related to skin cancers but also discovered five new protein-coding variants linked to conditions like lipomas and systemic lupus erythematosus.
Dermoscopy Training Course Improves Ophthalmologists' Accuracy in Diagnosing Atypical Pigmented Periorbital Skin Lesions.
Diagnostics (Basel)
November 2024
Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy.
Article Synopsis
- Facial pigmented skin lesions are common, especially in South-European countries, and can be either malignant or benign; diagnosing them can be challenging, even for specialists like dermatologists.* -
- A study was conducted to assess the impact of a one-day dermoscopy training course on ophthalmologists, focusing on their ability to evaluate periorbital pigmented lesions through clinical and dermoscopic analysis.* -
- Results showed that before the training, ophthalmologists had an accuracy of 63.7%, but after the course, their sensitivity improved, indicating a positive effect of the training on their diagnostic skills.*
Collision of Basal Cell Carcinoma with Apocrine-Sebaceous-Follicular Unit Neoplasms.
Dermatopathology (Basel)
October 2024
Dermatology Department, Doctor Jose Molina Orosa Hospital of Lanzarote, 35500 Arrecife, Spain.
Article Synopsis
- Tumor collisions, a rare occurrence with a 0.0017% incidence rate, often involve seborrheic keratosis, melanocytic nevi, and basal cell carcinoma (BCC), and are generally considered incidental events.
- A retrospective study was conducted analyzing hospital records to identify collisions between BCCs or squamous cell carcinoma (SCC) and apocrine-sebaceous-follicular unit (ASFu) neoplasms from 2005 to 2017.
- The study identified 12 collision cases involving BCC and ASFu tumors, primarily in immunosuppressed patients, with many neoplasms located beneath the BCC, leading to new insights and hypotheses about these tumor interactions
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!