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| http://dx.doi.org/10.1038/s41392-022-01172-y | DOI Listing |
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Fibroblast growth factor 21 alleviated atopic march by inhibiting the differentiation of type 2 helper T cells.
Int Immunopharmacol
January 2025
Biopharmaceutical Lab, College of Life Science, Northeast Agricultural University, Harbin 150030, China; Research Center of Genetic Engineering of Pharmaceuticals of Heilongjiang Province, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of Agricultural Biological Functional Gene, Northeast Agricultural University, Harbin 150030, China. Electronic address:
Background: The blood FGF21 expression has been previously suggested to increase in patients developing atopic dermatitis (AD) and asthma. However, its impact on atopic march is rarely analyzed. The present work focused on investigating the role of Fibroblast Growth Factor 21(FGF21) in atopic march mice and its underlying mechanisms.
View Article and Find Full Text PDFRhFGF21 protected PC12 cells against mitochondrial apoptosis triggered by HO via the AKT-mediated ROS signaling pathway.
Exp Cell Res
January 2025
Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, China; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:
Article Synopsis
- Oxidative stress is a key factor in neurodegenerative diseases by damaging neurons, making the reduction of reactive oxygen species (ROS) a potential treatment approach.
- Fibroblast growth factor 21 (FGF21) has shown protective effects on neuronal cells, as it can enhance cell viability by reducing mitochondrial apoptosis and lowering ROS levels.
- The research indicates that treatment with rhFGF21 increases the expression of p-AKT, which plays a critical role in mediating cell survival against oxidative stress, suggesting that FGF21's protective effects are linked to the AKT and ROS signaling pathway.
FGF21 Exhibits Neuroprotective Effects by Promoting 5-HTR-FGFR1 Heteroreceptor Complexes and Triggering MEK-ERK Signaling Pathway.
Mol Neurobiol
January 2025
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Approaches of promoting a neural milieu permissive for plasticity and resilience against neuronal injury are important strategies for the treatment of a range of neurological disorders. Fibroblast growth factor 21 (FGF21) which is known for its role as a potent regulator of glucose and energy metabolism has also proved to be neuroprotective against various mental diseases. However, the underlying molecular mechanisms remain elusive.
View Article and Find Full Text PDFIDOL alleviates the body weight by upregulating UCP-1 in mice.
Diabetes Obes Metab
January 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Anesthesiology, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Background: Given the potential role of brown adipose tissue (BAT) in stimulating energy expenditure, activating BAT can be an effective anti-obesity treatment. Here, we aimed to use adenoviruses to establish the effect of the inducible degrader of the low density lipoprotein receptor (IDOL) in the formation of BAT.
Methods: IDOL or green fluorescent protein was overexpressed by adenovirus and injected into the scapula of C57BL/6J mice and fed with high-fat diet for 12 weeks.
Environmental high temperature (heat stroke) causes articular cartilage damage in vivo and in vitro.
Ecotoxicol Environ Saf
December 2024
Spinal surgery, China-Japan Friendship Hospital, East Ying Hua Yuan Street, Chaoyang District, Beijing, China.
Heatstroke (HS) is gradually becoming a major challenge in the field of global public health with the trend of global warming. In recent years, extreme high-temperature weather events have occurred frequently in the world, which directly led to a significant increase in heatstroke. However, up to now, the potential pathological effects of HS on articular cartilage have not been revealed.
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