AI Article Synopsis
- - Drug nephrotoxicity is a significant cause of acute kidney injury (AKI), notably involving various antimicrobials.
- - AKI can range from mild kidney damage to severe function loss, sometimes necessitating renal replacement therapy.
- - Key risk factors for antimicrobial-induced AKI include existing chronic kidney issues and concurrent use of other harmful drugs; early detection and prevention strategies are essential to reduce AKI-related health risks.
Article Abstract
One of the common causes of acute kidney injury (AKI) is drug nephrotoxicity. A large group of drugs associated with AKI includes a considerable number of antimicrobials. Clinical manifestations range from mild forms of tubular damage to significant deterioration of renal function requiring renal replacement therapy. Several mechanisms have been described, although the most common are acute interstitial nephritis, acute tubular necrosis, crystalic nephropathy or proximal/distal tubulopathy with electrolyte abnormalities. General risk factors for antimicrobial-induced AKI include pre-existing chronic kidney disease and concomitant use of drugs with nephrotoxic potential. Prevention and early recognition of AKI are the standard approach to mitigate AKI and avoid morbidity.
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