Relationship of Noncoding RNA and Swine Viruses.

Background: Swine viruses are well known as a threat to the pig industry. Many signaling pathways and a number of proteins were discovered to participate in the immune responses to swine viruses. Noncoding RNAs (ncRNAs), comprising a different set of transcripts including housekeeping RNAs (for example, rRNAs and tRNAs) and regulatory RNAs (small RNAs and long ncRNAs), recently have been described as important regulators of viral infections regarding swine.

Summary: A growing number of studies have shown ncRNAs are an indispensable part in response to virus infection, involved not only in antiviral responses, but in many interactions between host and virus, some of which may benefit the certain types of swine virus.

Key Messages: Here, we review the relationship of ncRNA and viruses through several representative swine viruses. Further, we discuss the potential of using ncRNAs as antiviral biomarkers.