Two independent equations were recently proposed for estimating Lu-cetuximab cumulative activity, in a preclinical situation, from an initial Cu-cetuximab diagnostic scan acquired at peak time of decay-uncorrected () or decay-corrected () time-activity curve of trapped Cu-cetuximab, respectively. The standard uptake ratio (SUR) measured at or turned out to be a key metric in each equation, respectively. However, acquiring the diagnostic scan at or might be a limitation of the proposed method. Therefore, in an attempt to overcome this limitation, this note aims at theoretically investigating whether SUR() and/or SUR() could be derived from a diagnostic scan acquired at any time postinjection.
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| http://dx.doi.org/10.1089/cbr.2022.0046 | DOI Listing |
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