A metal-free regioselective γ-C(sp)-H sulfenylation of enaminones with heterocyclic thiols is reported. This transformation is efficient, mild, scalable, and environmentally friendly and tolerates a large variety of enaminones substrates and heterocyclic thiols. The utility of this strategy is demonstrated in a late-stage modification of bioactive natural products and drug derivatives.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.2c02824 | DOI Listing |
Publication Analysis
Top Keywords
γ-csp-h sulfenylation
8
sulfenylation enaminones
8
heterocyclic thiols
8
kio-mediated γ-csp-h
4
enaminones metal-free
4
metal-free regioselective
4
regioselective γ-csp-h
4
enaminones heterocyclic
4
thiols reported
4
reported transformation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!