AI Article Synopsis
- The study investigates the differences in sleep slow-wave (SW) transition between older adults with amnestic mild cognitive impairment (aMCI) and cognitively normal (CN) controls, focusing on the impact of obstructive sleep apnea (OSA).
- Findings reveal that those with aMCI exhibit a slower transition speed between negative and positive SW phases, which correlates with cognitive decline and memory issues, while CN participants show improvements.
- The results suggest that changes in SW metrics may reflect synaptic health, prompting future research to examine their relationship with biomarkers of synaptic integrity, particularly in the context of pathological aging.
Article Abstract
The sleep slow-wave (SW) transition between negative and positive phases is thought to mirror synaptic strength and likely depends on brain health. This transition shows significant age-related changes but has not been investigated in pathological aging. The present study aimed at comparing the transition speed and other characteristics of SW between older adults with amnestic mild cognitive impairment (aMCI) and cognitively normal (CN) controls with and without obstructive sleep apnea (OSA). We also examined the association of SW characteristics with the longitudinal changes of episodic memory and executive functions and the degree of subjective cognitive complaints. aMCI (no/mild OSA = 17; OSA = 15) and CN (no/mild OSA = 20; OSA = 17) participants underwent a night of polysomnography and a neuropsychological evaluation at baseline and 18 months later. Participants with aMCI had a significantly slower SW negative-to-positive-phase transition speed and a higher proportion of SW that are "slow-switchers" than CN participants. These SW measures in the frontal region were significantly correlated with memory decline and cognitive complaints in aMCI and cognitive improvements in CN participants. The transition speed of the SW that are "fast-switchers" was significantly slower in OSA compared to no or mild obstructive sleep apnea participants. The SW transition-related metrics showed opposite correlations with the longitudinal episodic memory changes depending on the participants' cognitive status. These relationships were particularly strong in participants with aMCI. As the changes of the SW transition-related metrics in pathological aging might reflect synaptic alterations, future studies should investigate whether these new metrics covary with biomarker levels of synaptic integrity in this population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832517 | PMC |
| http://dx.doi.org/10.1093/sleep/zsac246 | DOI Listing |
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