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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825334 | PMC |
| http://dx.doi.org/10.1093/neuonc/noac235 | DOI Listing |
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Historic cultural blocks are areas where a city's material cultural heritage and humanistic characteristics converge, showcasing the city's unique features and preserving rich and complete urban memories. Research on historic blocks primarily involves strategies related to protection, renewal, planning, and enhancement. However, there is a paucity of studies that explore the relationship between landscape value perception and tourist behavioral intentions from the perspective of recreation participants during the development and renewal of historic cultural blocks.
View Article and Find Full Text PDFAntibody-Drug Conjugates in Breast Cancer: The Road Towards Biologically-Informed Selection and Sequencing.
Curr Oncol Rep
January 2025
Susan F. Smith Center for Women's Cancers, Breast Oncology Program, Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
Purpose Of Review: In this review, we discuss evidence supporting the use of antibody-drug conjugates (ADCs) in breast cancer treatment, describe novel ADCs and combination regimens under development, and examine our current understanding of resistance mechanisms and biomarkers to guide ADC selection and sequencing.
Recent Findings: Three ADCs have proven benefit in patients with metastatic breast cancer: trastuzumab emtansine (T-DM1), trastuzumab deruxtecan (T-DXd), and sacituzumab govitecan (SG). There are over two hundred investigational ADCs on the horizon, as pre-clinical studies work to identify novel ADC targets and structures.
On the Road to Safety: Examining Children's Cycling Skills and Physical Activity Levels.
Children (Basel)
December 2024
University of Natural Resources and Life Sciences Vienna, Department of Landscape, Spatial and Infrastructure Sciences, Institute of Transport Studies, Peter Jordan St. 82, 1190 Vienna, Austria.
Background/objectives: Studies indicate a decline in children's physical activity (PA) levels, active mobility, and psychomotor skills, reflected in poorer cycling abilities. These trends are worrying given the rising prevalence of childhood obesity and sedentary lifestyles. This study assessed cycling skills among primary school children in Lower Austria, comparing self-perceptions with objective assessments, and explores the relationship between cycling skills, PA levels, and school performance, as well as the impact of cycling training on skill development.
View Article and Find Full Text PDFDomestic Use of E-Cargo Bikes and Other E-Micromobility: Protocol for a Multi-Centre, Mixed Methods Study.
Int J Environ Res Public Health
December 2024
Environmental Change Institute, University of Oxford, South Parks Road, Oxford OX1 3QY, UK.
Physical inactivity is a leading risk factor for non-communicable diseases. Climate change is now regarded as the biggest threat to global public health. Electric micromobility (e-micromobility, including e-bikes, e-cargo bikes, and e-scooters) has the potential to simultaneously increase people's overall physical activity while decreasing greenhouse gas emissions where it substitutes for motorised transport.
View Article and Find Full Text PDFOptimizing a link-based travel incentive scheme integrating personal carbon trading for low-carbon commuting.
J Environ Manage
January 2025
National Engineering Laboratory for Electric Vehicles, Beijing Institute of Technology, Beijing, China.
The pressing need to reduce greenhouse gas emissions and optimize traffic demand underlines the importance of effective travel demand management. Previous studies have explored budget-based and aggregated incentive programs, which diminish a heavy financial burden on governments and tend to be limited in contributing to effective behavior change in practice due to budget issues. This study proposes a personal carbon trading travel incentive (PCTTI) mechanism, to encourage private car commuters using low-carbon travel routes.
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