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Sarcopenia is defined as a muscle-wasting syndrome that occurs with accelerated aging, while cachexia is a severe wasting syndrome associated with conditions such as cancer and immunodeficiency disorders, which cannot be fully addressed through conventional nutritional supplementation. Sarcopenia can be considered a component of cachexia, with the bidirectional interplay between adipose tissue and skeletal muscle potentially serving as a molecular mechanism for both conditions. However, the underlying mechanisms differ.
View Article and Find Full Text PDFThe challenge of home and community older adult care in China: a survey of the capability of primary care physicians in providing geriatric healthcare services.
Front Public Health
December 2024
Kangda College of Nanjing Medical University, Lianyungang, China.
Introduction: In the context of ageing at home and in the community, healthcare services for older adult people in China are mainly provided by primary care physicians (PCPs). This study aimed to understand the level of geriatric healthcare service capability of PCPs in China and to give recommendations for improving care.
Methods: We surveyed PCPs in the eastern, central, and western regions of China, using a combination of multi-stage stratified cluster sampling and typical sampling.
Aging is the major risk factor for most human diseases and represents a major socio-economical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic dysregulation has been proposed as a key driver of the aging process.
View Article and Find Full Text PDFSample multiplexing is an emerging method in single-cell RNA sequencing (scRNA-seq) that addresses high costs and batch effects. Current multiplexing schemes use DNA labels to barcode cell samples but are limited in their stability and extent of labeling across heterogeneous cell populations. Here, we introduce Nanocoding using lipid nanoparticles (LNPs) for high barcode labeling density in multiplexed scRNA-seq.
View Article and Find Full Text PDFThe role of mitochondria in aging, cell death, and tumor immunity.
Front Immunol
December 2024
Department of Medicine, University of Florida (UF) Health Cancer Center, University of Florida, Gainesville, FL, United States.
Mitochondria are essential double-membrane organelles with intricate structures and diverse functions within cells. Under normal physiological conditions, mitochondria regulate cellular metabolism and maintain energy homeostasis via the electron transport chain, mediate stem cell fate, and modulate reactive oxygen species production, playing a pivotal role in energy supply and lifespan extension. However, mitochondrial dysfunction can lead to various pathological changes, including cellular aging, necrosis, dysregulated tumor immunity, and the initiation and progression of cancer.
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