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Engineering Acid-Promoted Two-Photon Ratiometric Nanoprobes for Evaluating HClO in Lysosomes and Inflammatory Bowel Disease.
ACS Appl Mater Interfaces
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Anhui Provincial Key Laboratory of Biomedical Materials and Chemical Measurement, Laboratory of Functionalized Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, P. R. China.
HClO is considered a potential contributing factor and biomarker of inflammatory bowel disease (IBD). Accurate monitoring of lysosomal HClO is important for further developing specific diagnostic and therapeutic schedules for IBD. However, only rare types of fluorescent probes have been reported for detecting HClO in IBD so far.
View Article and Find Full Text PDFA pH/GSH Dual-Responsive Triple Synergistic Bimetallic Nanocatalyst for Enhanced Tumor Chemodynamic Therapy.
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January 2025
Department of Thyroid Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710000, China.
Chemodynamic therapy (CDT) has garnered significant attention in the field of tumor therapy due to its ability to convert overexpressed hydrogen peroxide (HO) in tumors into highly toxic hydroxyl radicals (•OH) through metal ion-mediated catalysis. However, the effectiveness of CDT is hindered by low catalyst efficiency, insufficient intra-tumor HO level, and excessive glutathione (GSH). In this study, a pH/GSH dual responsive bimetallic nanocatalytic system (CuFeMOF@GOx@Mem) is developed by modifying red blood cell membranes onto glucose oxidase (GOx)-loaded Fe-Cu bimetallic MOFs, enhancing the efficacy of CDT through a triple-enhanced way by HO self-supply, catalysts self-cycling, and GSH self-elimination.
View Article and Find Full Text PDFAmorphous/Crystalline Urchin-Like TiO SERS Platform for Selective Recognition and Efficient Identification of Glutathione.
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January 2025
Ningbo Institute of Materials Technology and Engineering, CAS, Chinese Academy of Science, Ningbo, 315201, China.
Glutathione serves as a common biomarkers in tumor diagnosis and treatment. The levels of its intracellular concentration permit detailed investigation of the tumor microenvironment. However, low polarization and weak Raman scattering cross-section make direct and indirect Raman detection challenging.
View Article and Find Full Text PDFRobust Multi-Subtype Identification of Breast Cancer Pathological Images Based on a Dual-Branch Frequency Domain Fusion Network.
Sensors (Basel)
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School of Mechanical and Electrical Engineering, China Jiliang University, Hangzhou 310018, China.
Breast cancer (BC) is one of the most lethal cancers worldwide, and its early diagnosis is critical for improving patient survival rates. However, the extraction of key information from complex medical images and the attainment of high-precision classification present a significant challenge. In the field of signal processing, texture-rich images typically exhibit periodic patterns and structures, which are manifested as significant energy concentrations at specific frequencies in the frequency domain.
View Article and Find Full Text PDFDHCT-GAN: Improving EEG Signal Quality with a Dual-Branch Hybrid CNN-Transformer Network.
Sensors (Basel)
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Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai 519031, China.
Electroencephalogram (EEG) signals are important bioelectrical signals widely used in brain activity studies, cognitive mechanism research, and the diagnosis and treatment of neurological disorders. However, EEG signals are often influenced by various physiological artifacts, which can significantly affect data analysis and diagnosis. Recently, deep learning-based EEG denoising methods have exhibited unique advantages over traditional methods.
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